Am Fam Physician. 2016 Oct 15;94(8):664-665.
Which analgesics are most effective in treating patients with degenerative joint disease (DJD) of the hip or knee?
In patients with hip or knee DJD, all analgesics are more effective than placebo in relieving pain and improving function. Although paracetamol (acetaminophen) is the least effective of all the drugs studied, it still may be the first treatment for these patients because of its safety profile. Move on to other agents, if necessary, according to the patient's response. (Level of Evidence = 1a −)
These authors searched the Cochrane Central Register of Controlled Trials to identify randomized trials comparing nonsteroidal anti-inflammatory drugs, paracetamol, and placebo in patients with DJD
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