POEMs

All Analgesics Are Better Than Placebo in Patients with Knee or Hip DJD

 


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Am Fam Physician. 2016 Oct 15;94(8):664-665.

Clinical Question

Which analgesics are most effective in treating patients with degenerative joint disease (DJD) of the hip or knee?

Bottom Line

In patients with hip or knee DJD, all analgesics are more effective than placebo in relieving pain and improving function. Although paracetamol (acetaminophen) is the least effective of all the drugs studied, it still may be the first treatment for these patients because of its safety profile. Move on to other agents, if necessary, according to the patient's response. (Level of Evidence = 1a −)

Synopsis

These authors searched the Cochrane Central Register of Controlled Trials to identify randomized trials comparing nonsteroidal anti-inflammatory drugs, paracetamol, and placebo in patients with DJD

POEMs (patient-oriented evidence that matters) are provided by EssentialEvidence Plus, a point-of-care clinical decision support system published by Wiley-Blackwell. For more information, please see http://www.essentialevidenceplus.com. Copyright Wiley-Blackwell. Used with permission.

For definitions of levels of evidence used in POEMs, see http://www.essentialevidenceplus.com/product/ebm_loe.cfm?show=oxford.

To subscribe to a free podcast of these and other POEMs that appear in AFP, search in iTunes for “POEM of the Week” or go to http://goo.gl/3niWXb.

This series is coordinated by Sumi Sexton, MD, Associate Deputy Editor.

A collection of POEMs published in AFP is available at http://www.aafp.org/afp/poems.



 

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