Opioid Analgesia Hard to Tolerate and Not Effective for Chronic Low Back Pain
Am Fam Physician. 2016 Nov 1;94(9):753-757.
Is opioid analgesic treatment effective in patients with low back pain?
Effective pain control in patients with low back pain is still elusive. Approximately one-half of all patients with low back pain who take an opioid analgesic will stop treatment because of ineffectiveness or adverse effects. Patients staying the course will experience, on average, a small decrease in pain relative to patients who take placebo (similar to the benefit from nonsteroidal anti-inflammatory drugs) and will not have improved function. (Level of Evidence = 1a)
To identify randomized controlled trials that enrolled patients with nonspecific low back pain, published in any language, and evaluated an opioid analgesic, these researchers searched five databases
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