Cervical Treatment Associated with Adverse Obstetric Outcomes
Am Fam Physician. 2016 Dec 1;94(11):933a-936.
Is cervical treatment for preinvasive and early invasive disease associated with subsequent adverse obstetric outcomes?
Cervical treatments for dysplasia and early cervical carcinoma are associated with subsequent risk of preterm birth. Excisional treatments carry higher risk than ablative treatments, and multiple treatments carry higher risk than single treatments. The frequency and severity of prematurity-related outcomes increase with increasing cone depth and volume. (Level of Evidence = 2a)
This report is a meta-analysis of observational studies to assess the associations between local treatments for cervical intraepithelial neoplasia or early invasive carcinoma and subsequent obstetric outcomes. The authors included 71 studies (70 cohort, one case-control) with 65,082 treated women
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