POEMs

CA 125 Relatively Specific for Diagnosing Endometriosis

 

Am Fam Physician. 2017 Jan 15;95(2):122.

Clinical Question

Is serum cancer antigen (CA) 125 an accurate noninvasive test for diagnosing endometriosis in symptomatic women?

Bottom Line

For women with symptoms suggestive of endometriosis, serum CA 125 is a relatively specific (93%) and noninvasive test. It can be used to make a presumptive diagnosis in cases for which a medical management approach is being considered without having to perform a (diagnostic standard) laparoscopic procedure to confirm. At minimum, pelvic ultrasonography to assess for other conditions (ovarian cancer or uterine fibroids) that can raise CA 125 levels is needed. CA 125 is not a sensitive test for endometriosis (52%), and therefore not

POEMs (patient-oriented evidence that matters) are provided by EssentialEvidence Plus, a point-of-care clinical decision support system published by Wiley-Blackwell. For more information, please see http://www.essentialevidenceplus.com. Copyright Wiley-Blackwell. Used with permission.

For definitions of levels of evidence used in POEMs, see http://www.essentialevidenceplus.com/product/ebm_loe.cfm?show=oxford.

To subscribe to a free podcast of these and other POEMs that appear in AFP, search in iTunes for “POEM of the Week” or go to http://goo.gl/3niWXb.

This series is coordinated by Sumi Sexton, MD, Associate Deputy Editor.

A collection of POEMs published in AFP is available at http://www.aafp.org/afp/poems.


 

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