POEMs

Sertraline Reduces Risk of Depression in Adults After Traumatic Brain Injury

 

Am Fam Physician. 2017 Feb 1;95(3):194.

Clinical Question

Does sertraline (Zoloft) reduce the risk of depression in adults following traumatic brain injury (TBI)?

Bottom Line

This study found that sertraline is more effective than placebo (number needed to treat = 6) in preventing the onset of a major depressive disorder in adults following a TBI. This study included patients with mild, moderate, and severe TBI. (Level of Evidence = 1b−)

Synopsis

Depressive disorders are a common and disabling complication after TBI. These investigators identified patients (N = 94) 18 to 85 years of age with a diagnosis of closed (nonpenetrating) TBI according to Glasgow Coma Scale (GCS) scores and computed tomographic

POEMs (patient-oriented evidence that matters) are provided by EssentialEvidence Plus, a point-of-care clinical decision support system published by Wiley-Blackwell. For more information, please see http://www.essentialevidenceplus.com. Copyright Wiley-Blackwell. Used with permission.

For definitions of levels of evidence used in POEMs, see http://www.essentialevidenceplus.com/product/ebm_loe.cfm?show=oxford.

To subscribe to a free podcast of these and other POEMs that appear in AFP, search in iTunes for “POEM of the Week” or go to http://goo.gl/3niWXb.

This series is coordinated by Sumi Sexton, MD, Associate Deputy Editor.

A collection of POEMs published in AFP is available at http://www.aafp.org/afp/poems.


 

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