Sertraline Reduces Risk of Depression in Adults After Traumatic Brain Injury
Am Fam Physician. 2017 Feb 1;95(3):194.
Does sertraline (Zoloft) reduce the risk of depression in adults following traumatic brain injury (TBI)?
This study found that sertraline is more effective than placebo (number needed to treat = 6) in preventing the onset of a major depressive disorder in adults following a TBI. This study included patients with mild, moderate, and severe TBI. (Level of Evidence = 1b−)
Depressive disorders are a common and disabling complication after TBI. These investigators identified patients (N = 94) 18 to 85 years of age with a diagnosis of closed (nonpenetrating) TBI according to Glasgow Coma Scale (GCS) scores and computed tomographic
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