Sertraline Reduces Risk of Depression in Adults After Traumatic Brain Injury


Am Fam Physician. 2017 Feb 1;95(3):194.

Clinical Question

Does sertraline (Zoloft) reduce the risk of depression in adults following traumatic brain injury (TBI)?

Bottom Line

This study found that sertraline is more effective than placebo (number needed to treat = 6) in preventing the onset of a major depressive disorder in adults following a TBI. This study included patients with mild, moderate, and severe TBI. (Level of Evidence = 1b−)


Depressive disorders are a common and disabling complication after TBI. These investigators identified patients (N = 94) 18 to 85 years of age with a diagnosis of closed (nonpenetrating) TBI according to Glasgow Coma Scale (GCS) scores and computed tomographic

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Apr 15, 2017

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