Semaglutide Reduces CV Events in High-Risk Patients with Type 2 Diabetes Mellitus
Am Fam Physician. 2017 Mar 15;95(6):396.
Does semaglutide reduce the likelihood of subsequent cardiovascular (CV) events in patients with type 2 diabetes mellitus and known CV or chronic kidney disease?
Semaglutide significantly reduced the composite outcome of CV death, nonfatal myocardial infarction, and nonfatal stroke (number needed to treat [NNT] = 43 over 2.1 years). It was generally well tolerated, and it reduced body weight by approximately 6.4 to 9.5 lb (2.9 to 4.3 kg). Although pricing is not available, similar drugs are priced at approximately $700 per month in the United States. One harm was a small increase in complications of retinopathy, especially vitreous hemorrhage. It is important to remember that this was a very high-risk group with a mean age of 65 years; most had known ischemic heart disease. (Level of Evidence = 1a)
Semaglutide is a glucagon-like peptide-1 analogue that has a long half-life, allowing once-weekly administration as a subcutaneous injection. This study was designed as a noninferiority
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