If You Give Amoxicillin/Clavulanate to Six- to 23-Month-Olds with AOM, 10 Days Is Preferable to Five Days
Am Fam Physician. 2017 Apr 1;95(7):457.
Is five days of amoxicillin/clavulanate (Augmentin) non-inferior to 10 days of amoxicillin/clavulanate in children with acute otitis media (AOM)?
These authors begin with the assumption that we should treat children who have AOM with amoxicillin/clavulanate. They demonstrated that outcomes were slightly better with 10 days of treatment compared with five days of treatment in this group of six- to 23-month-olds with rigorously confirmed AOM. The greatest benefit was in children one to two years of age who had more severe pain and fever. In children with less severe symptoms, observation should still be the preferred option, as recommended by the American Academy of Family Physicians guidelines, accompanied by appropriate treatment of pain and fever. (Level of Evidence = 1b)
A previous study by the same lead author (N Engl J Med. 2011;364(2):105–115) found some support for antibiotics in children younger than two years with AOM for the outcome of sustained resolution of symptoms at 14 days (67%
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