Choosing Wisely:

Don’t perform maternal serologic studies for cytomegalovirus (CMV) and toxoplasmosis as part of routine prenatal laboratory studies.

Rationale and Comments: Routine serologic screening of pregnant women for CMV and toxoplasmosis is not recommended due to poor predictive value of these tests and potential for harm due to false positive results. Serologic screening during pregnancy for both diseases should be reserved for situations in which there is clinical or ultrasound suspicion of maternal or fetal infection.
Sponsoring Organizations:
  • Society for Maternal-Fetal Medicine
  • Sources:
  • Expert consensus
  • Disciplines:
  • Infectious disease
  • Obstetrical
  • References: • Society for Maternal-Fetal Medicine (SMFM), Hughes BL, Gyamfi-Bannerman C. Society for Maternal-Fetal Medicine Consult Series #39: Diagnosis and antenatal management of congenital cytomegalovirus (CMV) infection. Am J Obstet Gynecol. 2016 (in press).
    • American College of Obstetricians and Gynecologists. Practice Bulletin #151: Cytomegalovirus, Parvovirus B19, varicella zoster, and toxoplasmosis in pregnancy. Obstet Gynecol. 2015 Jun;125(6):1510-25.

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