FPIN's Clinical Inquiries

Clinical Inquiries from the Family Physicians Inquiries Network (FPIN) provide short, concise, evidence-based answers to clinical questions common in family medicine. The answers include a summary of the evidence and commentary that puts the answers into perspective.

Mar 15, 2012 Issue
Medications for Weight Loss in Patients with Type 2 Diabetes Mellitus
Fluoxetine (Prozac) and orlistat (Xenical) produce modest short-term weight loss, but their long-term benefits are unclear and their safety is uncertain.

Feb 15, 2012 Issue
Treatment of HSV Infection in Late Pregnancy
Pregnant women with a primary or recurrent episode of genital HSV infection who are later than 36 weeks of gestation should be treated with acyclovir (Zovirax) or valacyclovir (Valtrex) for viral suppression.

Feb 1, 2012 Issue
Human Parathyroid Hormone for Treating Osteoporosis
Human parathyroid hormone should be used in patients with severe osteoporosis to decrease the rate of vertebral and nonvertebral fractures.

Jan 15, 2012 Issue
Screening Mammography for Reducing Breast Cancer Mortality
Screening mammography reduces breast cancer mortality in women 40 to 49 years of age who have an average risk of breast cancer.

Dec 15, 2011 Issue
Antibody Testing for Systemic Lupus Erythematosus
Antibody testing plays an important role when assessing patients, but should not be used alone to diagnose SLE.

Dec 1, 2011 Issue
Treatment of Nongenital Warts
Topical salicylic acid, cryotherapy, and topical fluorouracil are effective for treating nongenital warts.

Nov 15, 2011 Issue
Ginger for the Treatment of Nausea and Vomiting in Pregnancy
Ginger can be safely used to reduce nausea and vomiting in pregnancy.

Nov 1, 2011 Issue
Antidepressants for the Treatment of Insomnia in Patients with Depression
There is no single antidepressant or class of antidepressants that is most effective for the treatment of insomnia in patients with depression. The use of antidepressant medications can have a positive impact on sleep physiology, but does not seem to improve subjective ratings of sleep quality.

Oct 15, 2011 Issue
Managing Intoeing in Children
Intoeing can be accurately diagnosed using a history, physical examination, and torsional profile.

Oct 1, 2011 Issue
Improving Medication Adherence in Patients with Comorbidities
Interventions that involve pharmacists to review, simplify, and monitor medication use significantly improve adherence in patients with multiple medical conditions.

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