FPIN's Clinical Inquiries

Clinical Inquiries from the Family Practice Inquiries Network (FPIN) provide short, concise, evidence-based answers to clinical questions common in family medicine. The answers include a summary of the evidence and commentary that puts the answers into perspective.

Feb 15, 2010 Issue
Combination Therapy for Postmenopausal Osteoporosis
There is insufficient evidence to recommend combination therapy for the routine management of postmenopausal osteoporosis.

Dec 15, 2009 Issue
Aspirin Use in Children for Fever or Viral Syndromes
Aspirin should not be used to treat acute febrile viral illness in children.

Oct 15, 2009 Issue
Treatment for Anogenital Molluscum Contagiosum
There is no evidence from comparative trials to suggest a single best treatment method for anogenital molluscum contagiosum. Randomized controlled trials suggest self-administered topical imiquimod or podophyllotoxin cream is effective for resolving lesions.

Aug 15, 2009 Issue
Hip Pain in Preschool-Age Children
Evidence is lacking on the most common causes of hip pain in children because most data come from cohort studies and include referred patients. Based on these studies, transient synovitis is the most common cause of hip pain in preschool-age children, accounting for more than 80 percent of cases.

Jun 15, 2009 Issue
Effective Management of Flatulence
Probiotics and rifaximin (Xifaxan) have been shown to reduce total number of flatus episodes and associated discomfort.

Apr 15, 2009 Issue
Treatment of Otitis Media with Perforated Tympanic Membrane
Acute otitis media with tympanic membrane perforation in children should be treated with an oral antibiotic.

Feb 1, 2009 Issue
Aspirin in Patients with Actue Ischemic Stroke
Aspirin in a daily dose of 160 to 300 mg initiated within 48 hours of symptom onset results in a net decrease in morbidity and mortality caused by acute ischemic stroke, based on a systematic review), regardless of the availability of computed tomography (CT).

Nov 1, 2008 Issue
Management of Cervical Lymphadenitis in Children
Cervical lymphadenitis, defined as an acute symptomatic enlargement of the cervical lymph nodes, is a common condition in children of all ages. Most cases of cervical lymphadenitis in children are self-limited and can safely be monitored for spontaneous resolution over four to six weeks.

Sep 1, 2008 Issue
Effect of Antiepileptic Drugs on Oral Contraceptives
We found no studies that measure, or even estimate, any increase in pregnancy rates in women taking antiepileptic drugs. Antiepileptic drugs known to induce the hepatic cytochrome P450 (CYP450) isoenzyme cause decreased sex hormone levels in women taking oral contraceptives, raising the potential for decreased effectiveness of oral contraceptives and increased risk of unplanned pregnancy.

Aug 1, 2008 Issue
Antiepileptic Drug Level Monitoring
Routine monitoring of antiepileptic drug levels does not alter seizure or side effect rates.

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