This department includes information about new drugs from the perspective of the five attributes to be considered when weighing the advantages of one drug over another: Safety, Tolerability, Effectiveness, Price, and Simplicity.

Aug 15, 2012 Issue
Ulipristal (Ella) for Emergency Contraception
Ulipristal is a prescription-only emergency contraceptive. It is at least as effective as levonorgestrel when administered within 72 hours of unprotected sexual intercourse, and is more effective than levonorgestrel in the 72- to 120-hour window.

Jun 15, 2012 Issue
Dutasteride/Tamsulosin (Jalyn) for Benign Prostatic Hyperplasia
Jalyn offers the convenience of taking one medication instead of two. Although monotherapy with dutasteride or tamsulosin is beneficial for many men, the combination drug is slightly better than either component alone at decreasing symptom scores; however, these benefits are of questionable clinical significance.

May 1, 2012 Issue
Tapentadol (Nucynta) for Treatment of Pain
Tapentadol is a DEA schedule II opioid medication with a safety profile, duration of action, frequency of dosing, and analgesic effect similar to those of other oral narcotics, although it is more expensive. At low doses, immediate-release tapentadol is better tolerated than oxycodone in terms of gastrointestinal adverse effects, and in the long term, extended-release tapentadol is better tolerated than controlled-release oxycodone.

Feb 15, 2012 Issue
Denosumab (Prolia) for Treatment of Postmenopausal Osteoporosis
Prolia is an expensive method of preventing osteoporotic hip fractures, and is associated with significant adverse effects. Safer, less expensive options exist for preventing fracture in high-risk women.

Dec 15, 2011 Issue
Dabigatran (Pradaxa) for Prevention of Stroke in Atrial Fibrillation
Dabigatran is superior to warfarin for stroke prevention in patients with atrial fibrillation, with similar rates of major bleeding. Because it does not require laboratory monitoring, dabigatran therapy is less complicated than warfarin therapy, but it costs significantly more.

Oct 15, 2011 Issue
Tranexemic Acid (Lysteda) for Cyclic Heavy Menstrual Bleeding
Tranexamic acid is a nonhormonal option that reduces menstrual blood loss and improves quality of life in patients with heavy menstrual bleeding. It is more expensive than nonsteroidal anti-inflammatory drugs and hormonal therapies, but is an option when these treatments are not desired or recommended.

Aug 15, 2011 Issue
Doxepin (Silenor) for Insomnia
In older patients with primary insomnia, Silenor can increase duration of sleep without next-day effects. However, it does not significantly decrease the time to sleep onset, and it is less effective in younger adults.

Jun 15, 2011 Issue
Adapelene/Benzoyl Peroxide (Epiduo) for Acne Vulgaris
Adapalene/benzoyl peroxide is as effective as other combination products for the treatment of acne. Once-daily application is an advantage in terms of simplicity and adherence to therapy, but the cost is much higher than that of the individual components sold separately; this may create a barrier to adherence.

Apr 15, 2011 Issue
Alvimopan (Entereg) for the Treatment of Postoperative Ileus
Use of alvimopan should be restricted to patients at a higher risk of postoperative ileus following abdominal surgeries, such as hospitalized patients undergoing bowel resection with primary anastomosis. It is an expensive option with limited indications; head-to-head studies with similar agents are needed. Alvimopan is not available for the treatment of nonhospitalized patients.

Feb 15, 2011 Issue
Guanfacine (Intuniv) for Attention-Deficit/Hyperactivity Disorder
Guanfacine is an effective short-term treatment option for ADHD in children six to 12 years of age. Sedation is a marked problem in many children. Patients should take the medication daily to avoid adverse effects that occur with abrupt discontinuation or when the guanfacine is restarted.

Pages: Previous 1 2 3 4 5 6 7 8 9 10 Next

Email Alerts

Don't miss a single issue. Sign up for the free AFP email table of contents.

Sign Up Now