AFP DEPARTMENT COLLECTION

Clinical Evidence Handbook

This collection is a series of chapters excerpted from Clinical Evidence Handbook, published by the BMJ Publishing Group. They offer systematic reviews of evidence supporting key treatment recommendations on important clinical topics.

Apr 15, 2011 Issue
Constipation in Adults
What are the effects of nondrug interventions, fiber supplements, and paraffin in adults with idiopathic chronic constipation? What are the effects of stimulant and osmotic laxatives? What are the effects of prostaglandin derivatives and 5-hydroxytryptamine 4 receptor agonists in persons with idiopathic chronic constipation?


Mar 15, 2011 Issue
Diabetic Nephropathy: Preventing Progression
What are the effects of treatments to prevent progression of nephropathy in persons with type 1 and type 2 diabetes and early and late nephropathy?


Feb 15, 2011 Issue
Epilepsy (Generalized and Partial)
What are the effects of monotherapy in generalized epilepsy (tonic-clonic type)? What are the effects of additional treatments in persons with drug-resistant generalized epilepsy?


Jan 15, 2011 Issue
Shoulder Pain
What are the effects of oral and topical drug treatment in persons with shoulder pain?What are the effects of local injections, nondrug and surgical treatments in persons with shoulder pain?


Dec 15, 2010 Issue
End-stage Renal Disease
What are the effects of different doses for peritoneal dialysis? What are the effects of different doses and membrane fluxes for hemodialysis? What are the effects of interventions aimed at preventing secondary complications?


Nov 15, 2010 Issue
Urinary Tract Infection in Children
What are the effects of treatment for acute UTI in children? What are the effects of interventions to prevent recurrence of UTI in children?


Oct 15, 2010 Issue
Obesity in Adults
What are the effects of drug treatments in adults with obesity? What are the effects of bariatric surgery in adults with morbid obesity?


Sep 15, 2010 Issue
Bacterial Conjunctivitis
What are the effects of empiric treatment in adults and children with suspected bacterial conjunctivitis? What are the effects of treatment in adults and children with culture-confirmed bacterial or suspected or clinically confirmed gonococcal conjunctivitis?


Aug 15, 2010 Issue
Schizophrenia (Maintenance Treatment)
What are the effects of treatments to reduce relapse rates in persons with schizophrenia? What are the effects of interventions in persons with schizophrenia who are resistant to standard antipsychotics? What are the effects of interventions to improve adherence to medication?


Jul 15, 2010 Issue
Primary Prevention of CVD: Physical Activity
Does counseling to increase physical activity lead to increased physical activity in healthy persons without existing CVD? What are the health benefits of increasing physical activity in relation to cardiovascular outcomes in healthy persons without existing CVD?


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