Jun 15, 2006 Issue
Exenatide Injection (Byetta): Adjunctive Therapy for Glycemic Control [STEPS]

Exenatide is an injectable treatment for type 2 diabetes. Its use requires patient education and strict monitoring of glucose levels because of the difficulty of its administration; therefore, it may not be a safe or practical option for patients who are not willing or able to administer exenatide correctly.

Feb 15, 2006 Issue
Preventing CVD in Patients with Type 1 Diabetes [Practice Guidelines]

A report that identifies ways to improve prevention and treatment of cardiovascular disease (CVD) in persons with type 1 diabetes has been released by the National Heart, Lung, and Blood Institute (NHLBI) and the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).

Feb 1, 2006 Issue
Are Alpha-glucosidase Inhibitors Effective for Control of Type 2 Diabetes? [Cochrane for Clinicians]

The use of alpha-glucosidase inhibitors has a modest effect on intermediate diabetes-control endpoints such as postprandial blood glucose, postprandial insulin levels, and A1C levels. There is no evidence, however, of improvement in mortality, morbidity, or quality of life. In comparisons with sulfo...

Dec 1, 2005 Issue
Diabetic Nephropathy [Clinical Evidence Handbook]

What are the effects of treatments in persons with type 1 diabetes and early or late nephropathy? What are the effects of treatments in persons with type 2 diabetes and early or late nephropathy?

Oct 1, 2005 Issue
AAP Clinical Report on Diabetic Retinopathy [Practice Guidelines]

A clinical report reviewing the risk factors and screening guidelines for diabetic retinopathy in children has been released by the American Academy of Pediatrics (AAP), in conjunction with the American Association for Pediatric Ophthalmology and Strabismus (AAPOS).

Sep 1, 2005 Issue
Short-Acting Insulin Analogues vs. Human Insulin for Diabetes [Cochrane for Clinicians]

For patients with type 2 diabetes, regular insulin and short-acting insulin analogues are equally effective in the treatment of diabetes and in lowering A1C levels. For patients with type 1 diabetes, short-acting analogues produce a slightly greater reduction of A1C levels than regular insulin. Regu...

Jul 1, 2005 Issue
Diabetic Nephropathy: Common Questions [Article]

Diabetic nephropathy, or diabetic kidney disease, affects 20 to 30 percent of patients with diabetes. It is a common cause of kidney failure. Diabetic nephropathy presents in its earliest stage with low levels of albumin (microalbuminuria) in the urine. The most practical method of screening for mic...

Jun 1, 2005 Issue
Evaluation and Prevention of Diabetic Neuropathy [Article]

Diabetic neuropathy is a debilitating disorder that occurs in nearly 50 percent of patients with diabetes. It is a late finding in type 1 diabetes but can be an early finding in type 2 diabetes. The primary types of diabetic neuropathy are sensorimotor and autonomic. Patients may present with only o...

May 1, 2005 Issue
Hyperosmolar Hyperglycemic State [Article]

Hyperosmolar hyperglycemic state is a life-threatening emergency manifested by marked elevation of blood glucose, hyperosmolarity, and little or no ketosis. With the dramatic increase in the prevalence of type 2 diabetes and the aging population, this condition may be encountered more frequently by ...

May 1, 2005 Issue
Diabetic Ketoacidosis [Article]

A diagnosis of diabetic ketoacidosis requires the patient's plasma glucose concentration to be above 250 mg per dL (although it usually is much higher), the pH level to be less than 7.30, and the bicarbonate level to be 18 mEq per L or less. Beta-hydroxybutyrate is a better measurement of the degree...

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