Diabetes Mellitus, Type 2

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Are Long-acting Insulin Analogues Better Than Isophane Insulin? - Cochrane for Clinicians

Choosing First-Line Therapy for Management of Type 2 Diabetes - AFP Journal Club

Management of Blood Glucose in Type 2 Diabetes Mellitus - Article

ABSTRACT: Evidence-based guidelines for the treatment of type 2 diabetes mellitus focus on three areas: intensive lifestyle intervention that includes at least 150 minutes per week of physical activity, weight loss with an initial goal of 7 percent of baseline weight, and a low-fat, reduced-calorie diet; aggressive management of cardiovascular risk factors (i.e., hypertension, dyslipidemia, and microalbuminuria) with the use of aspirin, statins, and angiotensin-converting enzyme inhibitors; and normalization of blood glucose levels (hemoglobin A1C level less than 7 percent). Insulin resistance, decreased insulin secretion, and increased hepatic glucose output are the hallmarks of type 2 diabetes, and each class of medication targets one or more of these defects. Metformin, which decreases hepatic glucose output and sensitizes peripheral tissues to insulin, has been shown to decrease mortality rates in patients with type 2 diabetes and is considered a first-line agent. Other medications include sulfonylureas and nonsulfonylurea secretagogues, alpha glucosidase inhibitors, and thiazolidinediones. Insulin can be used acutely in patients newly diagnosed with type 2 diabetes to normalize blood glucose, or it can be added to a regimen of oral medication to improve glycemic control. Except in patients taking multiple insulin injections, home monitoring of blood glucose levels has questionable utility, especially in relatively well-controlled patients. Its use should be tailored to the needs of the individual patient.

Dipeptidyl-peptidase-4 Inhibitors for Treatment of Type 2 Diabetes - Cochrane for Clinicians

Risk-Assessment Tools for Detecting Undiagnosed Diabetes - Point-of-Care Guides

Type 2 Diabetes: Separating Proven from Unproven Interventions - Editorials

Patient-Physician Partnering to Improve Chronic Disease Care - Improving Patient Care

Screening for Type 2 Diabetes Mellitus in Adults: Recommendation Statement - U.S. Preventive Services Task Force

Treatment of Type 2 Diabetes Mellitus: A Rational Approach Based on Its Pathophysiology - Editorials

Combination Therapy for Type 2 Diabetes - Editorials

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