Items in AFP with MESH term: Thiophenes

Is Prasugrel More Effective Than Clopidogrel in Patients with Acute Coronary Syndrome Scheduled for PCI? - AFP Journal Club


Duloxetine (Cymbalta) for Treatment of Major Depressive Disorder - STEPS


Treating Diabetic Peripheral Neuropathic Pain - Article

ABSTRACT: Diabetic peripheral neuropathic pain affects the functionality, mood, and sleep patterns of approximately 10 to 20 percent of patients with diabetes mellitus. Treatment goals include restoring function and improving pain control. Patients can realistically expect a 30 to 50 percent reduction in discomfort with improved functionality. The main classes of agents used to treat diabetic peripheral neuropathic pain include tricyclic antidepressants, anticonvulsants, serotonin-norepinephrine reuptake inhibitors, opiates and opiate-like substances, and topical medications. Physicians should ask patients whether they have tried complementary and alternative medicine therapies for their pain. Only two medications are approved specifically for the treatment of diabetic peripheral neuropathic pain: pregabalin and duloxetine. However, evidence supports the use of other therapies, and unless there are contraindications, tricyclic antidepressants are the first-line treatment. Because patients often have multiple comorbidities, physicians must consider potential adverse effects and possible drug interactions before prescribing a medication.


Is Rivaroxaban Noninferior to Standard Warfarin Therapy in Preventing Recurrent PE and DVT? - AFP Journal Club



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