This edition of FP Essentials™ will cover recent updates on metabolic syndrome. The content should include: impaired glucose tolerance; hyperlipidemia; nonalcoholic steatohepatitis; and polycystic ovarian syndrome. The content should emphasize recent, relevant literature rather than provide a general review of these four topics.
This edition of FP Essentials should be approximately 10,000 words in length, divided into four sections of approximately 2,500 words each, plus an abstract of no more than 200 words for each section, key practice recommendations, a maximum of 15 tables and figures, recommended readings, and references. This edition should focus on what is new in each topic and should answer the key questions listed for each section. Each section should begin with an illustrative case, similar to the examples provided, with modifications to emphasize key points; each case should have a conclusion that demonstrates resolution of the clinical situation. The references suggested here include information that should be considered in preparation of this FP Essentials. However, these references are only a useful starting point that should be used to identify additional information to review.
Example case: Kara, a 34-year-old obese woman, was found after obtaining blood work to have a random glucose level of 174 mg/dL. She has a family history of diabetes in her mother and sister, and her father had a myocardial infarction at age 60 years. She does not smoke. You obtain a fasting blood sugar, and it is 124 mg/dL. Kara is otherwise in good health. She returns to the office to discuss the test results and a treatment plan.
Key questions to consider:
Initial references to consider:
Example case: John is a 35-year-old obese man. He has a waist circumference of 110 cm (43.3 in), and laboratory test results have shown impaired glucose tolerance. You obtain a fasting lipid profile that shows total cholesterol of 260 mg/dL, low-density lipoprotein level of 200 mg/dL, high-density lipoprotein level of 35 mg/dL, and triglycerides levels of 250 mg/dL. Although his father died of a myocardial infraction at age 45 years, John is reluctant to start drug therapy for treatment of these lipid abnormalities.
Example case: Kathy is a 45-year-old obese woman who has been diagnosed with metabolic syndrome based on waist circumference, impaired glucose tolerance, and hyperlipidemia. She presented with abdominal pain and you obtained a chemistry profile, which showed elevated levels of aspartate transaminase and alanine transaminase. She denies any alcohol use and is not taking a statin or other drug that could cause elevated liver enzymes.
Example case: Grace is a 25-year-old woman who has been trying to get pregnant for 2 years. She says her menstrual periods have always been irregular, and she frequently goes several months without a period. On examination, you notice acne and mild hirsutism.
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