Pharmaceutical Preparations

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Off-label Use of Prescription Drugs - Editorials

Genomics and the Family Physician: Realizing the Potential - Editorials

Mind the Gap: Medicare Part D's Coverage Gaps May Affect Patient Adherence - Graham Center Policy One-Pagers

Out-of-Pocket Prescription Costs a Continuing Burden Under Medicare Part D - Graham Center Policy One-Pagers

Medicare Part D: Who Wins, Who Loses? - Graham Center Policy One-Pagers

Medicare Part D: Practical and Policy Implications for Family Physicians - Editorials

Acute Renal Failure - Clinical Evidence Handbook

Is Genetic Testing for Cytochrome P450 Polymorphisms Ready for Implementation? - Editorials

Drug Pricing in AFP--How Much Does a Drug Cost? - Editorials

Clinically Significant Drug Interactions - Article

ABSTRACT: A large number of drugs are introduced every year, and new interactions between medications are increasingly reported. Consequently, it is no longer practical for physicians to rely on memory alone to avoid potential drug interactions. Multiple drug regimens carry the risk of adverse interactions. Precipitant drugs modify the object drug's absorption, distribution, metabolism, excretion or actual clinical effect. Nonsteroidal anti-inflammatory drugs, antibiotics and, in particular, rifampin are common precipitant drugs prescribed in primary care practice. Drugs with a narrow therapeutic range or low therapeutic index are more likely to be the objects for serious drug interactions. Object drugs in common use include warfarin, fluoroquinolones, antiepileptic drugs, oral contraceptives, cisapride and 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors. Many other drugs, act as precipitants or objects, and a number of drugs act as both. Regularly updated manuals of drug interactions and CD-ROM-formatted programs are useful office references.

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