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Major Depression Comparative Effectiveness Study - Expanding DARTNet
Study Description and Methods
Specific Aims and Objectives
- Utilization Study—Conduct population-based cohort studies of incident (new) episodes of major depression using commercially available national claims data. Describe the patterns of use of antidepressants and combinations of other psychotropic drugs, both alone and in combination with psychotherapy. Examine patterns of treatment utilization for pediatric and adult populations separately, and compare primary care versus specialty mental health care diagnosing of major depression and prescribing of psychotropics.
- Comparative Effectiveness of Treatment for Major Depression—Utilize commercially available national claims data to evaluate the responsiveness and remission rates for major depression treatment and inform and expand knowledge on depression care.
- Comparative Safety Study of Antidepressants—Measure rates of adverse effects to include the most common medical side effects causing treatment discontinuation, and suicidality, including ideation and attempts.
Deborah Graham, MSPH
Assoc. Research Director
AAFP National Research Network