Each year in the United States, 2.2 million individuals experience diabetic foot ulcers, 2.5 million develop pressure sores, and more than 500,000 experience a burn to the skin. Family physicians are often the first to see individuals with these wounds. Initial treatment can determine whether the wound will heal properly or be complicated by infection, poor healing, or scarring. This FP EssentialsTM monograph will address the recent advances in general wound care, and the management of three wound conditions: diabetic foot ulcers, pressure sores, and burns.
The FP EssentialsTM monograph should be approximately 10,000 words in length, divided into four sections of approximately 2,500 words each, plus a preface, key practice recommendations, a maximum of 15 tables and figures, recommended readings, and references. The monograph should focus on what’s new in each topic and should answer the key questions listed for each section. Each section should begin with an illustrative case, similar to the examples provided, with modifications to emphasize key points. The references listed below include information that should be considered in preparation of this edition of FP EssentialsTM. However, these references are only a useful starting point that should be used to identify additional information to review.
Wound Care/Skin Ulcers
Section One: New and Emerging Approaches to Wound Care
Example case: Blair, a 5-year-old boy is brought to your office for acute care following a dog bite on the hand; the dog belongs to his neighbor. Blair has a 3-cm ragged, non-bleeding laceration on the middorsum of hand with no obvious tendon involvement. What is the appropriate approach to managing this wound?
Key questions to consider:
Key questions to consider:
- What is the best initial approach to wound management, regardless of type?
- What are the best types of dressings available for each of the four wound types discussed in the monograph?
- What are the best types of topical agents to use for each of these four wound types, and when should use of oral antibiotics be considered?
- When and for which types of wounds should adjuvant treatments, such as vacuum closure and hyperbaric oxygen, be considered?
- What biologic therapies are available for wound treatment, and when should they be considered?
- What is the best approach to a scar that may be disfiguring?
Initial references to consider:
- Vaneau M, Chaby G, Guilllot B, et al: Consensus panel recommendations for chronic and acute wound dressings. Arch Dermatol. 2007;143(10):1291-1294.
- Singer AJ, Dagum AB. Current management of acute cutaneous wounds. N Engl J Med. 2008;359(10):1037-1046 [Review].
- Grey JE, Healy B, Harding K. Antibiotic prophylaxis for minor dermatological surgery in primary care. BMJ. 2009;338:a2749.
- Enoch S, Grey JE, Harding KG. ABC of wound healing. Non-surgical and drug treatments. BMJ. 2006;332(7546):900-903 [Review].
- Enoch S, Grey JE, Harding KG. Recent advances and emerging treatments. BMJ. 2006;332(7547):962-965 [Review].
- Broughton G 2nd, Janis JE, Attinger CE. The basic science of wound healing. Plast Reconstr Surg. 2006;117(7 Suppl):12S-34S [Review].
- Ubbink DT, Westerbos SJ, Nelson EA, et al. A systematic review of topical negative pressure therapy for acute and chronic wounds. Br J Surg. 2008;95(6):685-692.
- Franz MG, Steed DL, Robson MC. Optimizing healing of the acute wound by minimizing complications. Curr Probl Surg. 2007;44(11):691-763 [Review].
- Reish RG, Eriksson E. Scars: a review of emerging and currently available therapies. Plast Reconstr Surg. 2008;122(4):1068-1078.
- Bulter PD, Longaker MT, Yang GP. Current progress in keloid research and treatment. J Am Coll Surg. 2008;206(4):731-741.
- Chaby G Senet P, Vaneau M, et al. Dressings for acute and chronic wounds: a systematic review. Arch Dermatol. 2007;143(10):1297-1304.
- Roeckl-Wiedmann I, Bennett M, Kranke P. Systematic review of hyperbaric oxygen in the management of chronic wounds. Br J Surg. 2005;92(1):24-32.
- Farion KJ, Osmond MH, Hartling L, et al. Tissue adhesives for traumatic lacerations in children and adults. Cochrane Database Syst Rev 2002;(3):CD003326.
- Singer AJ, Thode HC Jr. A review of the literature on octylcyanoacrylate tissue adhesive. Am J Surg. 2004;187(2):238-248.
- Steed DL. Clinical evaluation of recombinant human platelet-derived growth factor for the treatment of lower extremity ulcers. Plast Reconstr Surg. 2006; 117(7Suppl):143S-149S; discussion 150S-151S [Review].
- Ferfuson MW, Duncan J, Bond J, et al. Prophylactic administration of avotermin for improvement of skin scarring: three double-blind, placebo-controlled, phase I/II studies. Lancet. 2009;373(9671):1264-1274.
- Singer AJ, Quinn JV, Clark RE, et al; TraumaSeal StudyGroup. Closure of lacerations and incisions with octylcyanoacrylate: a multicenter randomized controlled trial. Surgery. 2002;131(3):270-276.
- Mody GN, Nirmal IA, Duraisamy S, et al. A blinded, prospective, randomized controlled trial of topical negative pressure wound closure in India. Ostomy Wound Manage. 2008;54(12):36-46.
Section Two: New Management Strategies for Diabetic Ulcer of the Foot
Example case: Dionne, a 58-year-old woman, has type 2 diabetes, hypertension, elevated cholesterol level, and peripheral vascular disease. She is obese and smokes one pack of cigarettes daily. She has difficulty adhering to the treatment regimen. When examining the feet, you find a large callus with surrounding cellulitis at the base of the left great toe. Dionne was unaware of this condition. What is the best approach to managing this foot condition?
Key questions to consider:
Key questions to consider:
- What is the best way to prevent diabetic ulcer of the foot?
- What classification system best describes diabetic ulcer of the foot?
- Which types of diabetic ulcers of the foot can be managed in the family physician’s office, and which require referral to a podiatric subspecialist? When should a surgeon become involved?
- Which diabetic ulcers of the foot should be treated with antibiotics, and what is the best way to determine the appropriate antibiotic?
- What is the best way to determine whether underlying osteomyelitis is present?
- When should off-loading be considered, and which method is best?
- When should hyperbaric oxygen therapy be used to treat a diabetic ulcer of the foot?
- What is the role of biologic therapy, and when should it be used?
- When would you consider referring a patient with such a wound to a subspecialist?
Initial references to consider:
- Boulton AJ, Armstrong DG, Albert SF, et al. Comprehensive foot examination and risk assessment: a report of the task force of the foot care interest group of the American Diabetes Association, with endorsement by the American Association of Clinical Endocrinologists. Diabetes Care. 2008;31(8):1679-1685.
- Falanga V. Wound healing and its impairment in the diabetic foot. Lancet. 2005;366(9498):1736-1743 [Review].
- Cavanagh PR, Lipsky BA, Bradbury AW, et al. Treatment for diabetic foot ulcers. Lancet. 2005;366(9498):1725-1735.
- Brem H, Sheehan P, Rosenberg HJ, et al. Evidence-based protocol for diabetic foot ulcers. Plast Reconstr Surg. 2006;117(7 Suppl):193S-209S; discussion 210S-211S.
- Singh N, Armstrong DG, Lipsky BA. Preventing foot ulcers in patients with diabetes. JAMA. 2005;293(2):217-228 [Review].
- Robinson AH, Pasapula C, Brodsky JW. Surgical aspects of the diabetic foot. J Bone Joint Surg Br. 2009; 91(1):1-7 [Review].
- Donovan A, Schweitzer ME. Current concepts in imaging diabetic pedal osteomyelitis. Radiol Clin North Am. 2008;46(6):1105-1124, vii.
- Butalia S, Palda VA, Sargeant RJ, et al. Does this patient with diabetes have osteomyelitis of the lower extremity? JAMA. 2008;299(7):806-813.
- Steed DL, Attinger C, Colaizzi T, et al. Guidelines for the treatment of diabetic ulcers. Wound Repair Regen. 2006;14(6):680-692. Also available at http://www3.interscience.wiley.com/cgi-bin/fulltext/118605280/PDFSTART.
- Letendre S, LaPorta G, O'Donnell E, et al: Pilot trial of biovance collange-based wound covering for diabetic ulcers. Adv Skin Wound Care. 2009;22(4):161-166.
- Rullan M, Cerdà L, Frontera G, et al. Treatment of chronic diabetic foot ulcers with bemiparin: a randomized, triple-blind, placebo-controlled clinical trial. Diabet Med. 2008;25(9):1090-1095.
- Scirè V, Leporati E, Teobaldi I, et al. Effectiveness and safety of using Podikon digital silicone padding in the primary prevention of neuropathic lesions in the forefoot of diabetic patients. J Am Podiatr Med Assoc. 2009;99(1):28-34.
- Lipsky BA, Holroyd KJ, Zasloff M. Topical versus systematic antimicrobial therapy for treating mildly infected diabetic foot ulcers: a randomized, controlled, double-blinded, multicenter trial of pexiganan cream. Clin Infect Dis. 2008;47(12):1537-1545.
Section Three: Prevention and Treatment of Pressure Sores
Example case: A 42-year-old, Raef, presents for a physical examination. He has been confined to a wheelchair for the past 14 years following a diving accident that resulted in a partial C7-C8 spinal injury. You notice a full-thickness loss of tissue with exposed subcutaneous fat at the base of the sacrum. No bone or muscle is visible. The area is surrounded by redness and warmth. What is the best approach to managing this pressure sore, and what can be done to prevent such sores from developing in the future?
Key questions to consider:
Key questions to consider:
- What is the latest staging system for pressure ulcers developed by the National Pressure Ulcer Advisory Panel?
- What is the most effective method for pressure relief for individuals confined to a wheelchair? For those individuals confined to bed?
- What is the best type of dressing to use for each stage of pressure ulcer?
- When should biologics, such as recombinant human platelet-derived growth factor and nerve growth factor, be used?
- Is maggot therapy effective in healing pressure ulcers and, if so, when should it be used?
- When should adjuvant therapy, such as vacuum therapy or hyperbaric oxygen therapy, be considered? Is there a role for electrical stimulation to improve healing?
- When should antibiotics be used, and what is the best method to determine the antibiotic choice?
- When should you consider referring a patient with such a wound to a subspecialist?
Initial references to consider:
- Regan MA, Teasell RW, Wolfe DL, et al; Spinal Cord Injury Rehabilitation Evidence Research Team. A systematic review of therapeutic interventions for pressure ulcers after spinal cord injury. Arch Phys Med Rehabil 2009;90(2):213-231.
- Reddy M, Gill SS, Kalkar SR, et al. Treatment of pressure ulcers: a systematic review. JAMA. 2008;300(22):2647-2662.
- Reddy M, Gill SS, Rochon PA. Preventing pressure ulcers: a systematic review. JAMA. 2006;296(8):974-984.
- Shirakawa M, Isseroff RR. Topical negative pressure devices: use for enhancement of healing chronic wounds. Arch Dermatol. 2005;141(11):1449-1453.
- Braden BJ, Maklebust J. Preventing pressure ulcers with the Braden scale: an update on this easy-to-use tool that assesses a patient’s risk. Am J Nurs. 2005;105(6):70-72 [Review]. Erratum in: Am J Nurs. 2005;105(8):16.
- Maklebust J. Pressure ulcers: the great insult. Nurs Clin North Am. 2005;40(2):365-389 [Review].
- Ebright JR. Microbiology of chronic leg and pressure ulcers: clinical significance and implications for treatment. Nurs Clin North Am. 2005;40(2):207-216 [Review].
- Edwards H, Courtney M, Finlayson K, et al. A randomised controlled trial of a community nursing intervention: improved quality of life and healing for clients with chronic leg ulcers. J Clin Nurs. 2009;18(11):1541-1549.
- Meaume S, Kerihuel JC, Constans T, et al. Efficacy and safety of ornithine alpha-ketoglutarate in heel pressure ulcers in elderly patients: results of a randomized controlled trial. J Nutr Health Aging. 2009;13(7):623-630.
- Dumville JC, Worthy G, Bland JM, et al. Larval therapy for leg ulcers (VenUS II): randomised controlled trial. BMJ. 2009;338:b773.
Section Four: Current Concepts in Management of Acute Burns in the Outpatient Setting
Example case: Lindsey, a 21-year-old college student, presents to your office soon after spilling boiling water on the left forearm and left leg. Several burned areas are visible, each about 5 cm in diameter. These burns are painful and pale pink with small blisters. Capillary refill of these areas is normal. What is the best immediate treatment for these burns, and how should they be managed in subsequent visits?
Key questions to consider:
Key questions to consider:
- What is the best first aid that should be administered for burns?
- How are burns assessed, and what is the latest classification system?
- Which burns can be managed safely in the office setting, and what are the indications for referral to a subspecialist?
- Should blisters from a burn be deroofed?
- What types of dressings are best for each burn type?
- What are the indications for biological dressings?
- What can be done to prevent hypertrophic scarring?
Initial references to consider:
- Enoch S, Roshan A, Shah M. Emergency and early management of burns and scalds. BMJ. 2009;338:b1037 [Review].
- Chapman TT. Burn scar and contracture management. J Trauma. 2007;62(6 Suppl):S8 [Review].
- Kramer G, Hoskins S, Copper N, et al. Emerging advances in burn resuscitation. J Trauma. 2007;62(6 Suppl):S71-S72.
- Wolf SE. Modern burn care. J Trauma. 2007;62(6 Suppl):S67 [Review].
- Pham TN, Gibran NS. Thermal and electrical injuries. Surg Clin North Am. 2007;87(1):185-206, vii-viii.
- Benson A, Dickson WA, Boyce DE. Burns. BMJ. 2006;332(7542):649-652 [Review]. Erratum in: BMJ. 2006;332(7544):649-652.
- Cone JB. What’s new in general surgery: burns and metabolism. J Am Coll Surg. 2005; 200(4):607-615.
- Tredget EE. The basis of fibrosis and wound healing disorders following thermal injury. J Trauma. 2007;62(6 Suppl):S8 [Review].
- Papini R. Management of burn injuries of various depths. BMJ. 2004;329(7458):158-160 [Review].
- Hettiaratchy S, Papini R. Initial management of a major burn: I – overview. BMJ. 2004;328(7455):1555-1557 [Review].
- Hudspith J, Rayatt S. First aid and treatment of minor burns. BMJ. 2004;328(7454):1487-1489.
- Harte D, Gordon J, Shaw M, et al. The use of pressure and silicone in hypertrophic scar management in burns patients: a pilot randomized controlled trial. J Burn Care Res. 2009;30(4):632-642.
- Ahuja RB, Gupta A, Gur R. A prospective double-blinded comparative analysis of framycetin and silver sulphadizine as topical agents for burns: a pilot study. Burns. 2009;35(5):672-676.
- Hirsch T, Ashkar W, Schumacher O, et al. Moist Exposed Burn Ointment (MEBO) in partial thickness burns – a randomized, comparative open mono-cener study on the efficacy of dermaheal (MEBO) ointment on thermal 2nd degree burns compared to conventional therapy. Eur J Med Res. 2008;13(11):505-510.
- Costagliola M, Agrosì M. Second-degree burns: a comparative, multicenter, randomized trial of hyaluronic acid plus sulfadiazine vs. silver sulfadiazine alone. Curr Med Res Opin. 2005;21(8):1235-1240.
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