American Academy of Family Physicians

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Activity 2: Thrombophylaxis in Atrial Fibrillation: A Case-Based Approach to Management

Evidence-based guidelines for the prevention of thromboembolic events in patients with atrial fibrillation (AF) are available, but many clinical situations arise that are not addressed by the guidelines. For example, patients with multiple comorbidities, patients with a history of peptic ulcer disease, and patients at high risk of bleeding often fall into the gray areas of stroke prevention.

Using patient cases, faculty reinforce principles of management addressed in the first activity in this series. Cases focus on deciding between anticoagulants and antiplatelet agents for low-risk patients, balancing bleeding risk against stroke risk, and the therapeutic role of new anticoagulant agents.

Learning Objectives

After completing this activity, family physicians will be better able to:
  • Demonstrate increased awareness of the range of assessment tools and evidence-based guidelines available to aid thrombotic risk stratification in AF and incorporate this knowledge into practice.
  • Describe the role of antithrombotic therapy in AF patients at risk of stroke and be aware of the implications of underprescribing.
  • Describe the safety and efficacy profile of the currently available antithrombotic therapies, including issues surrounding patient selection.
  • Describe the approach to dosing and therapeutic drug monitoring for antithrombotic therapy in AF patients at risk of stroke based on evidence-based guidelines, and incorporate this knowledge into the care of patients.
  • Outline strategies for risk reduction in challenging patient populations and incorporate this knowledge into practice.
  • Describe emerging antithrombotic therapies and other new developments on the prevention of stroke in AF, including issues surrounding patient selection and monitoring.

Accessing the Activity

LearningLink is hosted by AAFP's technology partner MedEdArchitects. To access the activities (and to allow us to track learner progress through the program), you will need a LearningLink account. The only information required is your name, email address, and member status. Create a LearningLink account.

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Acknowledgment of Support

This activity is supported by an educational grant from Boehringer Ingelheim Pharmaceuticals, Inc.

Afib and Stroke Prevention
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