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Activity 1: Thromboprophylaxis in Atrial Fibrillation: Current Issues and Challenges
Warfarin has long been the mainstay of anticoagulation therapy. In this activity, the faculty provide practical advice on optimizing warfarin therapy and improving patient adherence. In 2010, the first anticoagulant to serve as a viable alternative to warfarin was approved by the U.S. Food and Drug Administration; other new anticoagulants are in the pipeline. New options for anticoagulation therapy promise advantages such as fixed dosing, no need for blood level monitoring, and significantly fewer drug and food interactions. These new agents and their evolving therapeutic role are also discussed in this activity.
Lip GY, Watson T. Stroke prevention in atrial fibrillation -- things can only get better. Br J Clin Pharmacol 2007;64:575-7.
- Demonstrate increased awareness of the range of assessment tools and evidence-based guidelines available to aid thrombotic risk stratification in AF and incorporate this knowledge into practice.
- Describe the role of antithrombotic therapy in AF patients at risk of stroke and be aware of the implications of underprescribing.
- Describe the safety and efficacy profile of the currently available antithrombotic therapies, including issues surrounding patient selection.
- Describe the approach to dosing and therapeutic drug monitoring for antithrombotic therapy in AF patients at risk of stroke based on evidence-based guidelines and incorporate this knowledge into practice.
- Outline strategies for risk reduction in challenging patient populations and incorporate this knowledge into practice.
- Describe emerging antithrombotic therapies and other new developments on the prevention of stroke in AF, including issues surrounding patient selection and monitoring.
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Acknowledgment of Support
Activity 1: Current Issues and Challenges