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Check Out Evidence-based AHRQ Antidepressant Guides
By News Staff
Patient Guide
The guide is intended to help patients work with their physicians and other health care professionals to choose appropriate antidepressant medications. It teaches patients about the common signs and symptoms of depression; how to talk with physicians about depression; and about the benefits, potential side effects and serious risks of antidepressants. It also discusses how to use the information learned about various antidepressant options when talking with health care professionals.
Clinician Guide
Specifically, the guide includes information on a dozen second-generation antidepressants: bupropion, citalopram, duloxetine, escitalopram, fluoxetine, fluvoxamine, mirtazapine, nefazodone, paroxetine, sertraline, trazodone and venlafaxine. These antidepressants, which include selective serotonin reuptake inhibitors and serotonin and norepinephrine reuptake inhibitors, often are prescribed because first-generation antidepressants (e.g., tricyclic antidepressants) can cause intolerable side effects and carry high risks.
The clinician guide includes what it calls the "Clinical Bottom Line," which summarizes various uses and effects of these antidepressants. The publication gives guidance on phases of depression, selecting antidepressants, and potential side effects and risks of serious harm from these agents (i.e., suicide, serotonin syndrome). It also includes a table listing brand names, some recommended dosages and prices for the various drugs.
The clinician guide does not cover depression in children or adolescents, postpartum depression, or depression in people with coexisting psychiatric disorders. It also does not include information about tricyclic antidepressants, monoamine oxidase inhibitors or any alternative therapies.
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