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Clinician, Consumer Guides on Type 2 Diabetes, Autism Outline Therapy Options
Resources are Free for Physicians, Patients, Caregivers
By News Staff
Type 2 Diabetes
The guide does not cover nonmedical interventions, such as nutrition, physical activity or weight loss.
The "Clinical Bottom Line" section of the guide includes the following findings:
- on average, many monotherapies reduce hemoglobin A1c, or HbA1c, levels by 1 percent;
- on average, two-drug combination therapies reduce HbA1c by 1 percent more than monotherapies;
- metformin was associated with less weight gain compared with other monotherapies or combination therapies; and
- glucagon-like peptide-1 receptor agonists were associated with less weight gain than were second-generation sulfonylureas.
Story Highlights
- The Agency for Healthcare Research and Quality has released two sets of summary guides aimed at clinicians and consumers that discuss the treatment of adults with type 2 diabetes and therapies for children with autism.
- Both sets of guides are based on comparative effectiveness reviews of more than 150 clinical studies and cover the risks and benefits associated with various treatment options.
- The resources are available online, and free print copies also are available from the agency.
The related consumer guide reviews the risks, benefits and costs of 11 brand-name diabetes medications and their generic equivalents, as well as seven drug combinations.
Autism Therapy
The potential causes of autism are not addressed in the guide.
The "Clinical Bottom Line" section of the guide includes the following findings:
- Evidence indicates that aripiprazole and, to a lesser extent, risperidone reduce challenging and repetitive behaviors compared with placebo. Both drugs, however, are associated with significant weight gain, sedation and extrapyramidal effects.
- Secretin does not improve language, cognition, behavior, communication, autism symptom severity or socialization.
- Evidence is insufficient to understand the effectiveness, benefits or adverse events from any allied health or complementary and alternative medicine interventions, any educational interventions and most behavioral interventions.
Free print copies of the guides may be requested by email or by calling the AHRQ Publications Clearinghouse at (800) 358-9295.
Bladder Cancer Data Prompt Labeling Update for Pioglitazone
Patients on Diabetes Drug for Year or More at Increased Risk
(6/22/2011)
Manufacturer Alerting Physicians to Safety Issues With Liraglutide
(6/20/2011)
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