Clinical Preventive Service Recommendation

Aspirin Use to Prevent Cardiovascular Disease and Colorectal Cancer

Aspirin Prevention, Adults Younger than Age 50 Years

GRADE: I RECOMMENDATION

The AAFP concludes that the current evidence is insufficient to assess the balance of benefits and harms of initiating aspirin use for the primary prevention of CVD and CRC in adults younger than 50 years. (2016)

Grade Definition(www.uspreventiveservicestaskforce.org)

Clinical Considerations(www.uspreventiveservicestaskforce.org)

Aspirin Prevention, Adults 50 to 59 Years

GRADE: B RECOMMENDATION

The AAFP recommends initiating low-dose aspirin use for the primary prevention of cardiovascular disease (CVD) and colorectal cancer (CRC) in adults aged 50 to 59 years who have a 10% or greater 10-year CVD risk, are not at increased risk for bleeding, have a life expectancy of at least 10 years, and are willing to take low-dose aspirin daily for at least 10 years. (2016)

Grade Definition(www.uspreventiveservicestaskforce.org)

Clinical Considerations(www.uspreventiveservicestaskforce.org)

Aspirin Prevention, Adults 60 to 69 Years

GRADE: C RECOMMENDATION

The decision to initiate low-dose aspirin use for the primary prevention of CVD and CRC in adults aged 60 to 69 years who have a 10% or greater 10-year CVD risk should be an individual one. Persons who are not at increased risk for bleeding, have a life expectancy of at least 10 years, and are willing to take low-dose aspirin daily for at least 10 years are more likely to benefit. Persons who place a higher value on the potential benefits than the potential harms may choose to initiate low-dose aspirin. (2016)

Grade Definition(www.uspreventiveservicestaskforce.org)

Clinical Considerations(www.uspreventiveservicestaskforce.org)

Aspirin Prevention, Adults 70 Years and Older

GRADE: I RECOMMENDATION

The AAFP concludes that the current evidence is insufficient to assess the balance of benefits and harms of initiating aspirin use for the primary prevention of CVD and CRC in adults aged 70 years or older. (2016)

Grade Definition(www.uspreventiveservicestaskforce.org)

Clinical Considerations(www.uspreventiveservicestaskforce.org)


These recommendations are provided only as assistance for physicians making clinical decisions regarding the care of their patients. As such, they cannot substitute for the individual judgment brought to each clinical situation by the patient's family physician. As with all clinical reference resources, they reflect the best understanding of the science of medicine at the time of publication, but they should be used with the clear understanding that continued research may result in new knowledge and recommendations. These recommendations are only one element in the complex process of improving the health of America. To be effective, the recommendations must be implemented.