The AAFP recommends against routine testing for Factor V Leiden and/or prothrombin 2012G> (PT) in asymptomatic adult family members of patients with venous thromboembolism, for the purpose of considering primary prophylactic anticoagulation. This recommendation does not extend to patients with other risk factors for thrombosis such as contraception use. (2012)
Clinical Consideration: http://www.nature.com/gim/journal/v13/n1/pdf/gim9201111a.pdf (www.nature.com)
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Venous Thromboembolism -- Clinical Preventive Service Recommendation