Venous Thromboembolism, Genomics Testing
The AAFP recommends against routine testing for Factor V Leiden and/or prothrombin 2012G> (PT) in asymptomatic adult family members of patients with venous thromboembolism, for the purpose of considering primary prophylactic anticoagulation. This recommendation does not extend to patients with other risk factors for thrombosis such as contraception use. (2012)
Clinical Consideration: http://www.nature.com/gim/journal/v13/n1/pdf/gim9201111a.pdf (www.nature.com)
Endorsement of Clinical Practice Guideline for Hospitalized Patients
Venous Thromboembolism Prophylaxis in Hospitalized Patients - American College of Physicians (Endorsed with Qualifications* January 2013)
*Qualifications are: 1. there are three recommendations in the guideline and all three are upgraded based on lower-level evidence and 2. reviewers were concerned that for the first recommendation an assessment tool is needed and one is not provided.