This large-scale multi-center project titled Blacks and Exacerbations on LABA v. Triotropium (BELT), a subcontract with Harvard University, is designed to compare the effectiveness of long-acting beta agonists (LABA)/inhaled corticosteroids (ICS) versus triotropium/ICS in African-American patients with moderate to severe asthma.
The specific aims of this project are to:
1. To determine, in a one year practice-based, real-world, randomized, prospective, parallel group, longitudinal comparative effectiveness trial with clinically important outcomes, whether in self-identified African American patients with asthma, treatment with LABA/ICS is superior to use of a non-β-adrenergic bronchodilator (tiotropium) combined with ICS (Tio/ICS).
2. To determine, in the context of this trial, whether in the 20% of self-identified African American patients with asthma bearing Arg16Arg of ADRB2, treatment with LABA/ICS is superior to use of a non-β-adrenergic bronchodilator combined with ICS.
This project was conducted from September 2010 through September 2013.
This project is currently conducting analysis. Please check back in the near future for key findings and publications.
For additional information about this study, please contact:
Brian Manning, MPH, CHES
Associate Research Director
AAFP National Research Network
This study was funded by a grant from the Agency for Healthcare Research and Quality.
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BELT Asthma Study