• Preconception Care (Position Paper)


    As providers of preventive health and chronic disease care for men and women during their reproductive years, family physicians are well-positioned to proactively care for women, men, and families prior to, during, and after pregnancy. Preconception care is defined as individualized care for men and women that is focused on reducing maternal and fetal morbidity and mortality, increasing the chances of conception when pregnancy is desired, and providing contraceptive counseling to help prevent unintended pregnancies. The term “interconception care” is used when referring specifically to care provided between pregnancies. Details and risk factors associated with previous pregnancies are integral to interconception care. Because preconception care and interconception care address the same risk factors, the term “preconception care” is used throughout this position paper to include issues related to interconception care, unless a distinction is required.

    National attention to preconception care interventions dates back to 1980 when the inaugural Healthy People initiative included a focus on the reduction of unintended pregnancies.1 The health objectives set forth in this initiative were designed to address the disparities in unintended pregnancy rates related to age and racial/ethnic group.2 These disparities were often associated with maternal risk factors3, 4 and subsequent adverse reproductive outcomes.5, 6 Preconception health care remains a strategic objective of Healthy People 2020.7 Despite reductions in the number of maternal deaths worldwide 8- maternal deaths in the United States have increased and birth outcomes in the United States are worse than many other high-income and even some low-income countries.8 In 2006, the CDC released Recommendations to Improve Preconception Health and Health Care - United States: A Report of the CDC/ATSDR Preconception Care Work Group and the Select Panel on Preconception Care.9 This report was published in an effort to improve reproductive health outcomes.9 However, in spite of these national and international efforts, there continue to be barriers to incorporating preconception counseling into routine primary care.10

    To deliver on the promise to provide comprehensive care to patients, family physicians must possess the knowledge, ability, and skills to provide preconception care. This position paper discusses the critical role family physicians play in preconception care and provides evidence-based recommendations addressing reproductive health care, which is essential to the promotion of healthy families.

    Benefits of Preconception Care

    Infant mortality is often used as a key indicator of the overall health of the nation. The U.S. infant mortality rate is higher than the majority of other high-income countries and has remained relatively unchanged in the past decade.11, 12 Prematurity and birth defects account for the majority of infant deaths in the United States, and interventions aimed at improving prenatal care have not been able to substantially improve these outcomes.13-15 To make matters worse, U.S. women ages 18 to 44 have numerous preconception risk factors that can negatively impact maternal and infant health; approximately 50% of these women are considered overweight or obese, 19% are current smokers, 10% have hypertension, and 3% have diabetes.16  The maternal mortality rate is also high in the United States. A woman is 10 times more likely to die from childbirth related complications in the United States than in countries such as Austria or Poland and significant racial and ethnic disparities persist within the United States.17

    Many of the potentially modifiable risk factors that affect future pregnancy outcomes occur prior to pregnancy. Preconception care offers family physicians and their patients an opportunity to discuss these risk factors so they can be minimized. There are clinical practice guidelines based on good quality evidence for interventions that improve outcomes; this fact, strengthens the case for a more robust delivery of preconception services in routine primary care. Yet, the delivery of preconception care has been less than satisfactory due to numerous barriers.

    Barriers to Delivery of Preconception Care

    Traditionally, preconception care has focused on those patients planning a pregnancy and has primarily been delivered at the well-woman/preventive care visit.  However, since 50% of U.S. pregnancies are currently reported as unintended at the time of conception, the timing of addressing preconception risks poses a challenge.2Additionally, until they are pregnant, many women of child bearing age do not seek care for themselves or may not have access to care.18 There are also barriers to achieving goals of interconception care; these goals include educating women about avoiding unintended rapid repeat pregnancy, following up on health risks identified during pregnancy, and transitioning into appropriate primary care. The postpartum visit provides one opportunity for interconception care; however, patient attendance is not guaranteed. Some women may lose insurance coverage in the early postpartum period, which makes it difficult for them to get access to appropriate follow up care.16, 18

    In 1990, Jack and Culpepper identified seven barriers to preconception care19

    1. Women most in need of preconception care are the least likely to receive counseling
    2. Fragmented health care service delivery system
    3. Lack of treatment services for high-risk behaviors
    4. Inadequate physician reimbursement providing counseling services
    5. Lack of efficacy of counseling provided to unmotivated patients and their partner
    6. Limited number of conditions with evidence-based preconception interventions
    7. Lack of emphasis on risk assessment/health promotion in training programs.19

    Unfortunately, most of these barriers still exist. In a 2006 study, more than 95% of women surveyed recognized both the need to achieve optimal health prior to conception and the benefit of receiving information prior to conception.20However, a majority of women did not recall receiving any preconception counseling.20 In addition, while the majority of preconception counseling is important,21 most neither provide nor recommend counseling for their patients of childbearing age.22 Another study showed that in 2015, the number of women receiving preconception care services during ambulatory care visits (OB-GYN or FP) is only 14%.23

    Changes in the current healthcare landscape are removing some of these barriers through expanded health insurance coverage, improved reimbursement for preventive services, and public health initiatives. In addition, clinical practice guidelines based on good-quality evidence have been developed for preconception interventions that improve maternal and fetal outcomes.24 Family physicians have a unique opportunity to make an impact by improving maternal and fetal outcomes in the United States.

    Call to Action: Why Family Medicine Should Lead this Process

    Family physicians are ideally suited to lead healthcare system change related to preconception care.  They are the most frequent provider of ambulatory primary care services to women aged 18-44.25, 26 They also play a major role in providing ambulatory primary care services to children and men.25 Family physicians have an outstanding opportunity to address health issues (e.g. preconception risk reduction and chronic disease management) with women in multiple settings. For example, mothers are present at over 98% of well-child visits for children from birth to 2 years of age.27 If a woman missed her postpartum care visit, her family physician would likely have an opportunity to address maternal risks during her child’s routine health care visit.27

    Key Concept

    Providing quality preconception care is the responsibility of all primary care providers, not just those who provide maternity care or handle a high volume of women’s health. Innovative strategies that incorporate preconception care into routine primary care visits are needed. Transforming the way preconception care is delivered is critical to success.  In order to successfully deliver preconception care, family physicians must understand the risk factors for- and the realities of-unintended pregnancy; recognize the value of reproductive planning in reducing these risks, and assess preconception health risks during chronic disease management visits and acute care visits that are not specifically focused on women’s health or maternity issues. Preconception care is primary care and it should be a priority for primary care providers in all settings. The majority of preconception health topics are important whether a woman desires a future pregnancy or not, so providing quality preconception care is essentially providing quality women’s health care. The American Academy of Family Physicians (AAFP) outlines the following evidence-based recommendations for preconception care provided by family physicians.

    Preconception Interventions for Women

    During routine care for women, family physicians should identify patients’ childbearing goals, screen for risk factors that can impact future pregnancies, and provide indicated interventions to help women enter pregnancy in optimal health. The following are key interventions focused on addressing women’s contraceptive needs and preconception risk factors.

    A woman’s personal childbearing goals (i.e., her reproductive plan) should be considered for discussion at each visit, regardless of her reason for the visit because her plans may change on the basis of changing life circumstances.24,25 Reproductive plan discussions with women who want to become pregnant or who may become pregnant should include assessment of risks due to age, maternal or paternal conditions, obstetric history, and family history.28

    If a woman is sexually active and wants to prevent or delay pregnancy, comprehensive contraceptive services should be offered. All women who wish to delay or prevent pregnancy should be offered the following:

    • A full range of U.S. Food and Drug Administration (FDA)-approved contraceptive methods
    • An assessment to identify safe methods using the U.S. medical eligibility criteria,29
    • Counseling to help choose a contraceptive method
    • Prompt provision of the contraceptive method selected by the patient (preferably on site;- by referral-if necessary).30

    Family physicians should use a tiered approach to present information on reversible contraceptive methods; information about the most effective methods should be presented first, followed by information on less effective methods.31, 32 Counseling should include an explanation that long-acting reversible contraception (LARC) is safe and effective for most women, including adolescents and women who have never given birth.29 Family physicians should use shared decision making and tailor information about contraceptive methods  to focus on the patient’s preferences; for some patients, efficacy may not be the highest priority.33 Routine counselling about emergency contraceptive methods and provision of emergency contraception when needed should also be components of comprehensive family planning services.

    Due to the association of short interpregnancy levels with an increased risk of adverse perinatal outcomes, birth spacing should be discussed with patients.34 A meta-analysis on birth spacing and perinatal outcomes found that an interpregnancy interval of 18 to 24 months was associated with the lower risks of poor outcomes than intervals shorter than 6 months. Longer interpregnancy intervals (over 59 months) were also associated with poor outcomes. This interval is consistent with the WHO’s birth interval recommendation35 and the recommendation from the United Nations Children Fund (UNICEF) that breastfeeding for two years or more is optimal.36 The evidence on optimal birth spacing following spontaneous or induced abortion is currently insufficient. Counseling on birth spacing should be individualized on the basis of a woman’s reproductive plan. The family physician should take into account the health risks and benefits of the timing of the subsequent pregnancy and should discuss effective contraceptive options.

    All women of reproductive age should be advised to take a daily supplement (prenatal or multivitamin) of 400 to 800 mcg of folic acid daily and to consume a balanced, healthy diet of folate-rich foods.37 Folic acid supplementation starting prior to conception and continuing through 12 weeks of pregnancy reduces the risk of neural tube defects (NTDs) such as anencephaly, spina bifida, and encephalocoele.38 A higher dose of preconception folic acid (4 mg starting one month prior to attempting pregnancy and continuing through the first three months of pregnancy) is recommended for women at high risk for a pregnancy complicated by a NTD, and women who had a prior pregnancy complicated by a NTD, and women who have a personal or family history of NTD, insulin-dependent diabetes, or a seizure disorder (especially if it is treated with valproic acid or carbamazepine).39

    Management of overall health and chronic conditions is crucial for proper preconception care. Thirty-six percent of women aged 20 years and older are obese (body mass index [BM] greater than or equal to 30 kg/m2.40 It is essential to counsel women on obtaining a healthy weight prior to pregnancy because being obese increases the risk of pregnancy complications that include gestational diabetes, hypertension, macrosomia, birth trauma, and cesarean section,41 as well as increasing the risk of induced and spontaneous preterm birth.42 Compared with mothers who have a BMI in normal range, obese mothers have a higher likelihood of pregnancies affected by congenital anomalies, including NTDs, cardiovascular anomalies, and cleft palate.43 Women who have a BMI less than 18.5 kg/mare at increased risk for infertility,28 first trimester miscarriage,44 and preterm birth, and they are more likely to have an infant who has low birth weight.45  All women who have a BMI greater than 30 kg/m2 or less than 18.5 kg/m2 should be counseled about the risks their weight status poses to their own health and to future pregnancies; these patients should be offered specific strategies to improve the balance and quality of their diet and physical activity level.28

    Chronic hypertension can increase maternal and fetal morbidity and mortality during pregnancy.46 All women of reproductive age should have their blood pressure checked during routine care. Family physicians should provide counseling on lifestyle changes and appropriate medication adjustments for women who are diagnosed with hypertension.41 Women who have chronic hypertension should be counseled about preeclampsia and undergo a preconception assessment for ventricular hypertrophy, retinopathy, and renal disease to prevent end organ damage. Women who could become pregnant while taking angiotensin-converting enzyme (ACE) inhibitors or angiotensin II receptor blockers should be counseled about the adverse fetal effects of these medications and offered contraception. Women taking these medications who are planning a pregnancy or are not using an effective contraceptive method should strongly consider switching to a medication that is compatible with a healthy pregnancy.

    Current data shows that 3% of women of reproductive age are affected by diabetes.16 Poor glycemic control in the first trimester—before some women know they are pregnant—is associated with an increased risk of spontaneous abortion and congenital defects. 41,47 Other risks related to poor glycemic control include fetal macrosomia and associated birth trauma, stillbirth, and newborn hypoglycemia.  If blood glucose remains uncontrolled during pregnancy, women with diabetes may have progression of any underlying retinopathy and/or nephropathy.48, 49  Women who have diabetes also have an increased risk of high blood pressure and/or preeclampsia during pregnancy.49 Optimal glycemic control can reduce, but not eliminate, risks. All women of reproductive of childbearing age who have diabetes should be counseled about the importance of glycemic control before pregnancy. Women who have suboptimal diabetes control should be encouraged to use an effective contraceptive method.41 Assisting women who have diabetes and other chronic conditions with reproductive planning and optimal timing of pregnancy is an essential component of quality preconception care. 

    Counseling on medication usage is an important part of preconception care.28 Approximately 10% to 15% of congenital anomalies in the United States are attributed to prescription medication use during pegnancy.41 Since the late 1970s, the use of prescription medications in the earliest weeks of pregnancy has increased by more than 60%.50 One study found that in 2006 to 2008, 82% of women reported taking at least one prescription or over-the-counter (OTC) medication in the first trimester.51 Many commonly prescribed medications are considered unsafe in pregnancy.  Examples include ACE inhibitors, angiotensin receptor blockers (ARBs), warfarin, valproic acid, lithium, statins, and methotrexate. All women of childbearing age should be screened for the use of teratogenic medications and should be counseled about the potential impact of medications for chronic health conditions on pregnancy and fetal outcomes. When possible, known teratogenic medications should be switched to safer medications before conception. Women who have a chronic condition that poses a risk of serious morbidity to mother and infant, should be counseled to take the minimum number and the lowest dosages of medications that are essential to control the condition. For women who do not desire pregnancy, a plan for effective contraception should be discussed and initiated.  

    Preconception care should also include counseling on immunizations. All women of reproductive age should have their immunization status for tetanus-diphtheria-pertussis (Tdap); measles-mumps-rubella (MMR); and varicella reviewed annually and updated as indicated.52 In addition all women should be assessed annually to determine the need for vaccines that are recommended for those who have medical, occupational, or lifestyle risk factors for other infections.

    Mental health assessment should be included in preconception care.53 Mood and anxiety disorders are highly prevalent among women of reproductive age, and there is a high prevalence of new psychiatric illness or relapse of a preexisting illness during pregnancy.53 Controlling depression and anxiety disorders prior to pregnancy may help prevent negative outcomes for a woman’s pregnancy and her family; women of childbearing age should be screened for these disorders.53 If a woman who has depression or anxiety disorder could become pregnant or is planning a pregnancy, her family physician should inform her about the potential risk of untreated illness during pregnancy. She should also be informed about the risks and benefits of treatment options for depression and anxiety disorders during pregnancy. If necessary, medications should be adjusted prior to conception. This timing decreases the exposure of the fetus to multiple medications and allows the medication dose to be tapered in order to minimize the risk of withdrawal symptoms.53 Treatment for depression and anxiety disorders during pregnancy should be individualized.

    Another important part of preconception counseling is addressing lifestyle risks—including alcohol, tobacco, and substance use—and providing resources and support for lifestyle modifications. Alcohol use in pregnancy is the cause of fetal alcohol spectrum disorders (FASDs), a range of effects that include physical problems and behavioral and intellectual disabilities, and can have lifelong implications.39 All women of childbearing age should be screened for alcohol consumption and drug misuse. Family physicians should provide brief interventions that include describing the effects of drinking during pregnancy and warning that there are no safe levels of alcohol consumption during pregnancy.28,39

    Tobacco smoking in pregnancy is associated with numerous pregnancy complications including spontaneous abortion, stillbirth, low birthweight, preterm birth, placenta previa, placental abruption, and cleft lip/palate as well as an increased risk of sudden infant death syndrome (SIDS).54-56 Family physicians should screen all women of childbearing age for tobacco use.28 Patients who use tobacco should be provided with brief interventions that focus on the importance of reducing smoking—and ideally, completely stopping smoking—prior to pregnancy; interventions should also include discussing tobacco cessation medications and referring patients for intensive services.28, 57 Similarly, family physicians should screen women of childbearing age for misuse of other drugs (recreational and prescription) and should provide brief interventions with referral to a treatment center or higher level care, as indicated. Preconception care should also address occupational hazards and exposures, sexually transmitted infections (STIs), and physical and emotional abuse. For all women of childbearing age and their partners, family physicians should regularly assess STI risks, provide counseling and immunizations as indicated to prevent acquisition of STIs, and provide indicated STI testing and treatment.28, 58 Expedited Partner Therapy significantly reduces the risk of persistent infection.59 All women of reproductive age should be asked whether physical, sexual, or emotional violence from any source is happening currently or happened in the recent past, or during childhood.28 If a woman is being abused or has been abused in the recent past, the family physician should express concern and willingness to assist by giving support and referring the patient to appropriate organizations for help. Appropriate evaluation, counseling, and treatment for physical injuries, STIs, unintended pregnancy, and psychological trauma should be offered—including emergency contraception—if appropriate. For counseling, legal advice, and other services, women should be offered information about community agencies that specialize in cases of abuse.

    Table 1 - General Recommendations for Preconception Interventions for Women

    Questions/Care Considerations:

    Reproductive Planning

    Discuss reproductive goals and issues at each visit

    When pregnancy is desired, discuss medications, health conditions, and activities that may affect fertility

    Folic Acid

    All women of reproductive age should be advised to take folic acid and to consume a balanced, healthy diet of folate-rich foods. Women at high risk for NTDs should take higher levels of folic acid


    When pregnancy is not desired, discuss safe sex and effective contraceptive methods

    Offer a full range of contraceptive methods and provide appropriate contraceptive counseling that is tailored to each patient’s preference

    Counsel women on the importance of birth spacing

    Family and Genetic History

    Assess pregnancy risks on the basis of maternal age, maternal and paternal health, obstetric history, and family history


    All women with a BMI greater than or equal to 30 kg/m2 or less than 18.5 kg/m2 should be counseled about infertility risk and risks during and after pregnancy.

    Chronic Disease Management

    Hypertension: Women of reproductive age should have blood pressure checks during routine care. If diagnosed with hypertension, they should be counseled on lifestyle changes and medications that are safe in pregnancy.

    Diabetes: Women who have diabetes should be counseled about the importance of glycemic control.

    Depression/Anxiety Disorders: Women of reproductive age should be screened for depression and anxiety disorders and counseled about potential risks of untreated illness. Medications should be prescribed/adjusted prior to conception, if appropriate.

    Assess for use of teratogenic medications and optimize risk profile of medications  

    Social and Behavioral History

    Assess social history, lifestyle, and behavioral issues that may affect pregnancy

    All women of childbearing age should be screened for alcohol consumption, tobacco use, and drug use.


    Immunization status should be reviewed annually and updated as indicated.


    For all women of childbearing age and their partners, assess STI risk, provide counseling and immunizations as indicated to prevent acquisition of STIs, and provide indicated STI testing and treatment.

    Physical/Sexual/Emotional abuse




    All women of reproductive age should be screened for current, recent past, or childhood physical, sexual, or emotional interpersonal violence and referred to appropriate resources when needed.

    BMI = body mass index; NTDs = neural tube defects; STI = sexually transmitted infection

    Preconception Interventions for Men

    Most family planning and preconception care programs, research, and clinical practice guidelines have focused almost exclusively on women. Both the CDC and the U.S. Department of Health and Human Services (HHS) have called for improvements in meeting men’s reproductive health needs.7 Survey data have shown that the majority of men are in need of family planning or preconception care.60, 61 In spite of this perceived need, a man’s reproductive health before a partner’s pregnancy, and the effect of his health status on conception and pregnancy outcomes generally receive little attention, unless fertility issues arise.

    The goals of men’s preconception health are similar in many ways to those women’s goals.  The overall objective is to ensure optimal and positive outcomes of their reproductive and sexual behaviors, while minimizing the potential negative consequences of unhealthy lifestyle choices and unprotected sex. In addition, preconception care for a man should include counseling on the timing of pregnancy and on fathering children when he and his partner choose to do so; on overcoming fertility issues; and on ensuring healthy pregnancy for his partner and optimal post-partum outcomes for both his partner and their child or children.62, 63

    Effects on Fertility and Conception

    Researchers have studied various substances, anatomical variations, behaviors and environmental issues that may affect a man’s ability to contribute to a successful conception.  Studies of factors that affect sperm quality, quantity, concentration, and motility – have identified the following: 62-64

    • Health conditions such as diabetes, erectile dysfunction, and testicular conditions (e.g. varicocoele, history of testicular trauma, undescended testes, hypogonadism, retrograde ejaculation), may affect fertility to a certain degree.
    • Numerous medications (e.g. nifedipine, steroids, testosterone, colchicine, selective serotonin reuptake inhibitors [SSRIs], cimetidine, tetracyclines, allopurinol, opiates, ketoconazole) may alter the hypothalamic-pituitary-gonadal axis, and may reduce male libido, contribute to erectile dysfunction, and have toxic effects on sperm.65
    • Tobacco, alcohol and certain drugs (e.g. marijuana, cocaine) can affect spermatogenesis. 64
    • Exposure to environmental hazards, radiation, heat, pollutants, lead, mercury and other occupational chemicals has been shown to affect sperm quality.
    • Chemicals associated with woodworking, painting, making pottery and stained glass, and gun cleaning may affect sperm production.
    • Stress has been shown to negatively impact sperm morphology and concentration.
    • According to some studies, every 20 pounds above a man’s ideal body weight can lead to a 10% increase in the risk of infertility.66
    • A number of genetic disorders, (e.g. cystic fibrosis, Klinefelter syndrome, Kartagener syndrome, and polycystic kidney disease), may impair fertility and affect sperm quality.64

    Effects on Maternal and Fetal Outcomes

    A man’s lifestyle factors can have a direct impact on his partner’s pregnancy. These factors include tobacco smoking, which exposes the expectant mother to secondhand smoke and, potentially, leads to negative effects such as low birth weight, intra-uterine growth restriction (IUGR), and preterm birth67-69  as well as increasing the risk of SIDS. A man who has HIV or another STI directly puts his pregnant partner and the fetus at risk for pregnancy complications and maternal and fetal morbidity.62, 63 In addition, a growing body of literature that suggests a father’s involvement during pregnancy and delivery can have a positive effect on health outcomes for himself, his partner and their child or children.70 During wellness visits with men and adolescent boys, family physicians should consider discussing intimate partner violence, and coercive relationships, and promote respectful and consensual sexual relationships.71

    Paternal factors including genetics and age have been shown to have an effect on fetal outcomes. Screening for genetic conditions should be discussed and offered when appropriate.62, 64 Recent studies have pointed to a relationship between advanced paternal age and conditions such as autism, and schizophrenia and other mental health disorders. Schizophrenia was found to be two times more likely in the child whose father was older than 45 years of age at conception and three times as likely if the father was older than 50 years of age.  Similarly, a diagnosis of autism in the child is almost six times more likely in a child whose father was older than 40 years of age.72-74 

    Table 2 - General Recommendations for Preconception Interventions for Men

    Reproductive Planning

    Male reproductive health issues should be an integral part of every wellness visit.

    Assess the man’s understanding of reproduction and his reproductive plan.

    When a partner’s pregnancy is desired, discuss medications, conditions, and activities that may affect fertility

    Conduct a physical examination looking for signs or conditions that may affect fertility


    When a partner’s pregnancy is not desired, discuss effective contraceptive methods

    Family and Genetic History

    Assess family history and genetic susceptibility

    Social and Behavioral History

    Assess social history, lifestyle risk factors (Including smoking, substance abuse, and unsafe sex), and behavioral issues

    Assess for occupational hazards that may affect fertility


    Assess STI risk, provide counseling, and immunizations as indicated to prevent acquisition of STIs, and provide STI testing and treatment

    Physical/Sexual/Emotional Abuse

    Beginning in adolescence, consider screening for and counseling to avoid intimate partner violence and coercive relationships and promote respectful and consensual sexual relationships

    STI = sexually transmitted infection


    Preconception care is primary care, and providing quality preconception care is the responsibility of all primary care providers. Successful implementation requires transforming care delivery and making preconception care based on the best available evidence routine. The AAFP encourages members to follow these evidence-based recommendations to incorporate preconception care into all routine primary care visits and supports members’ efforts to improve maternal and fetal outcomes.


    1. Newes AG, et al. Alcohol Epidemiologic Data System, Surveillance Report #81: Trends in Underage Public Health Service, Promoting health/preventing disease: objectives for the nation. 1980.
    2. Finer, L.B. and M.R. Zolna, Unintended pregnancy in the United States: incidence and disparities, 2006.Contraception, 2011. 84(5): 478-485.
    3. D'Angelo, D., et al., Preconception and interconception health status of women who recently gave birth to a live-born infant--Pregnancy Risk Assessment Monitoring System (PRAMS), United States, 26 reporting areas, 2004.MMWR Surveill Summ, 2007. 56(10): 1-35.
    4. Phares, T.M., et al., Surveillance for disparities in maternal health-related behaviors--selected states, Pregnancy Risk Assessment Monitoring System (PRAMS), 2000-2001. MMWR Surveill Summ, 2004. 53(4): 1-13.
    5. Bryant, A.S., et al., Racial/ethnic disparities in obstetric outcomes and care: prevalence and determinants. Am J Obstet Gynecol, 2010. 202(4): 335-343.
    6. Rowland Hogue, C.J. and R.M. Silver, Racial and ethnic disparities in United States: stillbirth rates: trends, risk factors, and research needs. Semin Perinatol, 2011. 35(4): 221-233.
    7. U.S. Health and Human Services, Reproductive Health and Healthy People 2020. 2010.
    8. Kassebaum, N.J., et al., Global, regional, and national levels and causes of maternal mortality during 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet, 2014. 384(9947): 980-1004.
    9. Johnson, K., et al., Recommendations to improve preconception health and health care--United States. A report of the CDC/ATSDR Preconception Care Work Group and the Select Panel on Preconception Care. MMWR Recomm Rep, 2006. 55(Rr-6): 1-23.
    10. Dunlop, A.L., B. Jack, and K. Frey, National recommendations for preconception care: the essential role of the family physician. J Am Board Fam Med, 2007. 20(1): 81-84.
    11. MacDorman, M.F., et al., International comparisons of infant mortality and related factors: United States and Europe, 2010. Natl Vital Stat Rep, 2014. 63(5): 1-6.
    12. Mathews, T.J. and M.F. MacDorman, Infant mortality statistics from the 2004 period linked birth/infant death data set. Natl Vital Stat Rep, 2007. 55(14): 1-32.
    13. Mathews, T.J. and M.F. MacDorman, Infant mortality statistics from the 2008 period linked birth/infant death data set. Natl Vital Stat Rep, 2012. 60(5): 1-27.
    14. MacDorman, M.F., et al., Trends in preterm-related infant mortality by race and ethnicity, United States, 1999-2004. Int J Health Serv, 2007. 37(4): 635-641.
    15. National Center for Health Statistics. Final mortality data, 1990-1994 and period linked birth/infant death data, 1995-present.  June 19, 2015].
    16. Robbins, C.L., et al., Core state preconception health indicators - pregnancy risk assessment monitoring system and behavioral risk factor surveillance system, 2009. MMWR Surveill Summ, 2014. 63(3): 1-62.
    17. Save the Children Federation, The Urban Disadvantage, in State of the World's Mothers. 2015.
    18. Salganicoff, A., U.R. Ranji, and R. Wyn, Women and their Healthcare Providers, in Women and Health Care: National Profile Key Findings from the Women's Health Survey. 2005, Kaiser Family Foundation: Menlo Park, CA.
    19. Jack, B.W. and L. Culpepper, Preconception care. Risk reduction and health promotion in preparation for pregnancy. Jama, 1990. 264(9): 1147-1149.
    20. Frey, K.A. and J.A. Files, Preconception healthcare: what women know and believe. Matern Child Health J, 2006. 10(5 Suppl): S73-77.
    21. Morgan, M.A., et al., What obstetrician-gynecologists think of preconception care. Matern Child Health J, 2006. 10(5 Suppl): S59-65.
    22. Williams, J.L., et al., Health care provider knowledge and practices regarding folic acid, United States, 2002-2003.Matern Child Health J, 2006. 10(5 Suppl): S67-72.
    23. Bello, J.K., G. Rao, and D.B. Stulberg, Trends in contraceptive and preconception care in United States ambulatory practices. Fam Med, 2015. 47(4): 264-271.
    24. Atrash, H.K., et al., Preconception care for improving perinatal outcomes: the time to act. Matern Child Health J, 2006. 10(5 Suppl): S3-11.
    25. Ferrer, R.L., Pursuing equity: contact with primary care and specialist clinicians by demographics, insurance, and health status. Ann Fam Med, 2007. 5(6): 492-502.
    26. Cohen, D. and A. Coco, Do physicians address other medical problems during preventive gynecologic visits? J Am Board Fam Med, 2014. 27(1): 13-18.
    27. Frayne, D., et al., Addressing maternal behavioral risks during the interconception period to improve birth outcomes. 2014: North American Primary Care Research Group Annual Meeting.
    28. Jack, B.W., et al., The clinical content of preconception care: an overview and preparation of this supplement. Am J Obstet Gynecol, 2008. 199(6 Suppl 2): S266-279.
    29. U S. Medical Eligibility Criteria for Contraceptive Use, 2010. MMWR Recomm Rep, 2010. 59(RR-4): 1-86.
    30. Gavin, L., et al., Providing Quality Family Planning Services: Recommendations of CDC and the U.S. Office of Population Affairs. MMWR Recomm Rep, 2014. 63(RR-04): 1-54.
    31. Trussell, J., Contraceptive failure in the United States. Contraception, 2011. 83(5): 397-404.
    32. Winner, B., et al., Effectiveness of long-acting reversible contraception. N Engl J Med, 2012. 366(21): 1998-2007.
    33. Dehlendorf, C., C. Krajewski, and S. Borrero, Contraceptive counseling: best practices to ensure quality communication and enable effective contraceptive use. Clin Obstet Gynecol, 2014. 57(4): 659-673.
    34. Conde-Agudelo, A., A. Rosas-Bermudez, and A.C. Kafury-Goeta, Birth spacing and risk of adverse perinatal outcomes: a meta-analysis. Jama, 2006. 295(15): 1809-1823.
    35. World Health Organization Birth Spacing - Report from a WHO Technical Consultation. 2006.
    36. United Nations Children's Fund. Breastfeeding.  October 2, 2015].
    37. American Academy of Family Physicians. Neural tube defects, Prevention, Folic Acid Supplementation, Women. Clinical Preventive Service Recommendation  October 2, 2015].
    38. De-Regil, L.M., et al., Effects and safety of periconceptional folate supplementation for preventing birth defects.Cochrane Database Syst Rev, 2010(10): Cd007950.
    39. Before, Between, and Beyond Pregnancy: The National Preconception Curriculum and Resources Guide for Clinicians. 
    40. Fryar, C.D., M. Carroll, and C. Ogden Prevalence of Overweight, Obesity, and Extreme Obesity Among Adults: United States, 1960-1962 Through 2011-2012. NCHS Health E-Stat, 2014.
    41. Dunlop, A.L., et al., The clinical content of preconception care: women with chronic medical conditions. Am J Obstet Gynecol, 2008. 199(6 Suppl 2): S310-327.
    42. McDonald, S.D., et al., Overweight and obesity in mothers and risk of preterm birth and low birth weight infants: systematic review and meta-analyses. BMJ, 2010. 341: c3428.
    43. Stothard, K.J., et al., Maternal overweight and obesity and the risk of congenital anomalies: a systematic review and meta-analysis. Jama, 2009. 301(6): 636-650.
    44. Maconochie, N., et al., Risk factors for first trimester miscarriage--results from a UK-population-based case-control study. Bjog, 2007. 114(2): 170-186.
    45. Han, Z., et al., Maternal underweight and the risk of preterm birth and low birth weight: a systematic review and meta-analyses. Int J Epidemiol, 2011. 40(1): 65-101.
    46. Bramham, K., et al., Chronic hypertension and pregnancy outcomes: systematic review and meta-analysis. BMJ, 2014. 348: g2301.
    47. Mills, J.L., et al., Incidence of spontaneous abortion among normal women and insulin-dependent diabetic women whose pregnancies were identified within 21 days of conception. N Engl J Med, 1988. 319(25): 1617-1623.
    48. Hawthorne, G., Maternal complications in diabetic pregnancy. Best Pract Res Clin Obstet Gynaecol, 2011. 25(1): 77-90.
    49. Gordin, D., et al., Risk factors of hypertensive pregnancies in women with diabetes and the influence on their future life. Ann Med, 2014. 46(7): 498-502.
    50. Mitchell, A.A., et al., Medication use during pregnancy, with particular focus on prescription drugs: 1976-2008. Am J Obstet Gynecol, 2011. 205(1): 51.e51-58.
    51. Thorpe, P.G., et al., Medications in the first trimester of pregnancy: most common exposures and critical gaps in understanding fetal risk. Pharmacoepidemiol Drug Saf, 2013. 22(9): 1013-1018.
    52. American Academy of Family Physicians. Adult Immunization Schedule. 2015.
    53. Frieder, A., et al., The clinical content of preconception care: women with psychiatric conditions. Am J Obstet Gynecol, 2008. 199(6 Suppl 2): S328-332.
    54. Chamberlain, C., et al., Psychosocial interventions for supporting women to stop smoking in pregnancy. Cochrane Database Syst Rev, 2013. 10: Cd001055.
    55. U.S. Health and Human Services, The health consequences of smoking--50 years of progress:  A report of the surgeon general. 2014
    56. Andres, R.L. and M.C. Day, Perinatal complications associated with maternal tobacco use. Semin Neonatol, 2000. 5(3): 231-241.
    57. American Academy of Family Physicians. Tobacco Use, Pregnant Women. AAFP Clinical Preventive Services Recommendations 2003  August 2015].
    58. American Academy of Family Physicians. Summary of Recommendations for Clinical Preventive Services 2015.
    59. Centers for Disease Control and Prevention, Expedited partner therapy in the management of sexually transmitted diseases. 2006, Atlanta, GA: U.S. Department of Health and Human Services.
    60. Casey, F.E., et al., Family Planning and Preconception Health Among Men in Their Mid-30s: Developing Indicators and Describing Need. Am J Mens Health, 2014.
    61. Choiriyyah, I., et al., Men Aged 15-44 in Need of Preconception Care. Matern Child Health J, 2015.
    62. Warner, J.N. and K.A. Frey, The well-man visit: addressing a man's health to optimize pregnancy outcomes. J Am Board Fam Med, 2013. 26(2): 196-202.
    63. Frey, K.A., Male reproductive health and infertility. Prim Care, 2010. 37(3): 643-652, x.
    64. Frey, K.A., et al., The clinical content of preconception care: preconception care for men. Am J Obstet Gynecol, 2008. 199(6 Suppl 2): S389-395.
    65. Nudell, D.M., M.M. Monoski, and L.I. Lipshultz, Common medications and drugs: how they affect male fertility.Urol Clin North Am, 2002. 29(4): 965-973.
    66. Sallmen, M., et al., Reduced fertility among overweight and obese men. Epidemiology, 2006. 17(5): 520-523.
    67. Stotts, A.L., et al., Families at risk: home and car smoking among pregnant women attending a low-income, urban prenatal clinic. Nicotine Tob Res, 2014. 16(7): 1020-1025.
    68. World Health Organization, WHO Guidelines Approved by the Guidelines Review Committee, in WHO Recommendations for the Prevention and Management of Tobacco Use and Second-Hand Smoke Exposure in Pregnancy. 2013, World Health Organization, Copyright (c) World Health Organization 2013.: Geneva.
    69. Tong, V.T., et al., Clinical interventions to reduce secondhand smoke exposure among pregnant women: a systematic review. Tob Control, 2015. 24(3): 217-223.
    70. Plantin, L., A.A. Olukoya, and P. Ny, Positive health outcomes of fathers' involvement in pregnancy and childbirth paternal support:  a scope study literature review. Fathering, 2011. 9(1): 87-102.
    71. Carlson, J., et al., Strategies to Engage Men and Boys in Violence Prevention: A Global Organizational Perspective. Violence Against Women, 2015.
    72. Sandin, S., et al., Autism risk associated with parental age and with increasing difference in age between the parents. Mol Psychiatry, 2015.
    73. Malaspina, D., C. Gilman, and T.M. Kranz, Paternal age and mental health of offspring. Fertil Steril, 2015. 103(6): 1392-1396.
    74. McGrath, J.J., et al., A comprehensive assessment of parental age and psychiatric disorders. JAMA Psychiatry, 2014. 71(3): 301-309.
    (2015 December BOD) (2016 COD)