Preemptive Analgesia: Decreasing Pain Before It Starts


Am Fam Physician. 2001 May 15;63(10):1924-1925.

  Related Article

Physicians have a poor track record for relieving pain. A deplorably large number of studies during the past few decades document our persistent failure to adequately relieve pain in many patients, particularly in those undergoing surgery and those with cancer-related pain. There are many reasons for this failure, including simply prescribing inadequate dosages of appropriate analgesics.1 Obviously, though, our patients would certainly be grateful to us if they received adequate pain control after surgery.

However, in this issue of American Family Physician, Gottschalk and Smith2 take the concept of postoperative pain control one step further, or should I say one step back. They describe an innovative approach to relieving predictable pain, such as that which occurs following surgery, by the preemptive administration of analgesia before the procedure starts. They also review the theoretic mechanisms by which preemptive analgesia might desensitize the nervous system and thereby reduce pain perception and other untoward effects that can persist far beyond the recovery period. To work best, it seems that painful stimuli should be blocked as much as possible throughout the perioperative period.

Regardless of the mechanism, preemptive analgesia has been shown to be effective in a variety of surgical procedures. One notable success story was the enhanced ability of preemptive analgesia to reduce phantom limb pain and stump pain as long as one year after lower extremity amputation.3 Studies of analgesia used in circumcision have shown lasting beneficial effects on an infant's subsequent response to painful stimuli (in the form of vaccinations).4,5 Although not all studies of preemptive analgesia show positive effects, there seems to be little downside to controlling pain before it starts and following the intriguing promise of enhanced and persisting beneficial effects.

If preemptive analgesia stands up to further study, it will join the ranks of two other proven therapies that work best when given before an operation begins—low-dose heparin and prophylactic antibiotics. Family physicians can help ensure that their patients undergoing painful procedures receive adequate pain control not only after but, perhaps, also before.

Dr. Siwek is professor and chair of the Department of Family Medicine, Georgetown University Medical Center, Washington, D.C. He is also editor of American Family Physician.

Address correspondence to Jay Siwek, M.D., Department of Family Medicine, 212 Kober-Cogan Hall, Georgetown University Medical Center, 3800 Reservoir Rd., NW, Washington, DC 20007 (e-mail:AFP@family.georgetown.edu)


show all references

1. Siwek J. Twelve pitfalls of adequate pain control [Editorial]. Am Fam Physician. 1997;56:726–32....

2. Gottschalk A, Smith DS. New concepts in acute pain therapy: preemptive analgesia. Am Fam Physician. 2001;63:1979–841985–6.

3. Bach S, Noreng MF, Tjellden NU. Phantom limb pain in amputees during the first 12 months following limb amputation after preoperative lumbar epidural blockage. Pain. 1988;33:297–301.

4. Taddio A, Goldbach M, Ipp M, Stevens B, Koren G. Effect of neonatal circumcision on pain responses during vaccinations in boys. Lancet. 1995;345:291–2.

5. Taddio A, Katz J, Ilersich AL, Koren G. Effect of neonatal circumcision on pain response during subsequent routine vaccination. Lancet. 1997;349:599–603.



Copyright © 2001 by the American Academy of Family Physicians.
This content is owned by the AAFP. A person viewing it online may make one printout of the material and may use that printout only for his or her personal, non-commercial reference. This material may not otherwise be downloaded, copied, printed, stored, transmitted or reproduced in any medium, whether now known or later invented, except as authorized in writing by the AAFP. Contact afpserv@aafp.org for copyright questions and/or permission requests.

Want to use this article elsewhere? Get Permissions

More in Pubmed


Sep 2021

Access the latest issue of American Family Physician

Read the Issue

Email Alerts

Don't miss a single issue. Sign up for the free AFP email table of contents.

Sign Up Now

Navigate this Article