Am Fam Physician. 2002 Jan 15;65(2):172-173.

The article “Warfarin Therapy: Evolving Strategies in Anticoagulation” (February 1999, page 635) contained an error. On page 637, the third sentence of the third complete paragraph states: “Administration of loading doses has also been hypothesized to potentiate a hypocoagulable state because of severe depletion of protein C.” The sentence should have referred to a hypercoagulable state. Although warfarin is intended to produce a hypocoagulable state, loading doses of warfarin may paradoxically result in a hypercoagulable state because of significant reductions in protein C and protein S.


Copyright © 2002 by the American Academy of Family Physicians.
This content is owned by the AAFP. A person viewing it online may make one printout of the material and may use that printout only for his or her personal, non-commercial reference. This material may not otherwise be downloaded, copied, printed, stored, transmitted or reproduced in any medium, whether now known or later invented, except as authorized in writing by the AAFP. Contact for copyright questions and/or permission requests.

Want to use this article elsewhere? Get Permissions


Jun 15, 2021

Access the latest issue of American Family Physician

Read the Issue

Email Alerts

Don't miss a single issue. Sign up for the free AFP email table of contents.

Sign Up Now

Navigate this Article