Routine Stress Testing After Negative Biomarker Testing Is Seldom Helpful


Am Fam Physician. 2013 Nov 15;88(10):online.

Clinical Question

What is the diagnostic yield of performing routine stress testing in patients who have tested negative for acute coronary syndrome?

Bottom Line

Fewer than 1% of patients who undergo routine provocative cardiac testing after having two sets of negative serum troponin results following an episode of acute chest pain are identified as having potential benefit from revascularization (American Heart Association [AHA] class I or IIa). False-positive results are common. (Level of Evidence = 2b)


The AHA recommends provocative testing (e.g., stress testing) in patients with acute chest pain who have negative biomarker results, with the idea that it will identify patients who may benefit from revascularization. The researchers conducting this study identified all patients (n = 4,181) without previously identified coronary artery disease who presented to an emergency department over a six-year period. Acute coronary syndrome was ruled out in all included patients, and exercise stress testing (n = 512) or myocardial perfusion imaging (n = 3,669) was subsequently performed while they were still in the emergency department. Of these patients, 470 (11.2%) had inducible myocardial ischemia. Most were referred for further medical management, but 26.2% were deemed to require coronary angiography to determine whether they had obstructive disease that would benefit from revascularization. Of this group, 63 patients had obstructive disease, but only 28 patients had disease that would benefit from revascularization (AHA class I or IIa). As a result, the true positive rate was only 51.2% for patients undergoing provocative testing and subsequent angiography. Only 0.7% of patients who underwent provocative testing would have benefited from intervention, and an equal percentage had obstructive disease that would have been harmed by catheterization (e.g., AHA class III).

Study design: Cohort (retrospective)

Funding source: Self-funded or unfunded

Setting: Emergency department

Reference: Hermann LK, Newman DH, Pleasant WA, et al. Yield of routine provocative cardiac testing among patients in an emergency department-based chest pain unit. JAMA Intern Med.. 2013; 173( 12): 1128– 1133.

POEMs (patient-oriented evidence that matters) are provided by Essential Evidence Plus, a point-of-care clinical decision support system published by Wiley-Blackwell. For more information, please see http://www.essentialevidenceplus.com. Copyright Wiley-Blackwell. Used with permission.

For definitions of levels of evidence used in POEMs, see http://www.essentialevidenceplus.com/product/ebm_loe.cfm?show=oxford.



Want to use this article elsewhere? Get Permissions

More in AFP

Editor's Collections

Related Content

More in Pubmed


Nov 2021

Access the latest issue of American Family Physician

Read the Issue

Email Alerts

Don't miss a single issue. Sign up for the free AFP email table of contents.

Sign Up Now

Navigate this Article