Low High-Sensitivity Troponin I Level Accurate in Identifying Patients at Low Risk of Cardiac Events


Am Fam Physician. 2016 Apr 15;93(8):704a-705.

Clinical Question

Is the high-sensitivity troponin I assay accurate in identifying patients with suspected acute coronary syndromes who are at low risk of cardiac events?

Bottom Line

The high-sensitivity troponin I assay used in this study was fairly accurate in identifying patients with chest pain who are at low risk of cardiac events. (Level of Evidence = 1c−)


These authors conducted a two-part study in adults presenting to the emergency department with suspected acute coronary syndromes. Each of the participating departments had been randomized into the standard care arms of trials designed to determine if high-sensitivity troponin I levels will influence care and improve outcomes. In the first part, the derivation cohort, the researchers evaluated nearly 4,900 adults, 16% of whom had an acute myocardial infarction (MI) at the time of emergency department presentation and an additional handful who had a subsequent acute MI or died (1% and 2%, respectively) within 30 days. From this cohort, they determined that to achieve a 99.5% negative predictive value (determined a priori) a threshold value for high-sensitivity troponin I should be 5 nanograms per liter. In the second part of the study, the validation cohort, the researchers used two different groups and followed more than 1,400 patients for up to one year after enrollment. Approximately 0.5% of the patients with a low high-sensitivity troponin I level had an acute MI—nearly 100% negative predictive value. The researchers evaluated the performance across many subgroups (sex, age, prior heart disease, and so forth) and found no significant differences. After one year, 0.3% of the patients with a low high-sensitivity troponin I level had an incident acute MI and 0.3% had a cardiac death compared with 1.3% and 2.2% in those with elevated high-sensitivity troponin I level, respectively.

Study design: Cohort (prospective)

Funding source: Government

Setting: Emergency department

Reference: Shah AS, Anand A, Sandoval Y, et al.; High-STEACS investigators. High-sensitivity cardiac troponin I at presentation in patients with suspected acute coronary syndrome: a cohort study. Lancet. 2015; 386( 10012): 2481– 2488.

POEMs (patient-oriented evidence that matters) are provided by EssentialEvidence Plus, a point-of-care clinical decision support system published by Wiley-Blackwell. For more information, please see http://www.essentialevidenceplus.com. Copyright Wiley-Blackwell. Used with permission.

For definitions of levels of evidence used in POEMs, see http://www.essentialevidenceplus.com/product/ebm_loe.cfm?show=oxford.

To subscribe to a free podcast of these and other POEMs that appear in AFP,search in iTunes for “POEM of the Week” or go to http://goo.gl/3niWXb.

This series is coordinated by Sumi Sexton, MD, Associate Deputy Editor.

A collection of POEMs published in AFP is available at https://www.aafp.org/afp/poems.



Want to use this article elsewhere? Get Permissions

More in AFP

Editor's Collections

Related Content

More in Pubmed


May 2022

Access the latest issue of American Family Physician

Read the Issue

Email Alerts

Don't miss a single issue. Sign up for the free AFP email table of contents.

Sign Up Now

Navigate this Article