Photo Quiz
Progressive Hair Loss
Am Fam Physician. 2017 Feb 1;95(3):183-184.
A 22-year-old active-duty service member presented with gradually progressive patchy hair loss on the scalp that began six weeks earlier. He was given intralesional steroid injections to decrease the hair loss. He returned six months later with widespread hair loss over his scalp and body, with minor sparing of the axillae and pubic region. After a two-month course of sulfasalazine (Azulfidine), his symptoms did not improve, and he had complete hair loss. He had a history of patchy hair loss five years earlier. He was otherwise healthy.
On physical examination, there was no hair noted anywhere on his body (Figure 1). The nail plates had a rough surface with longitudinal ridging (Figure 2). There was no visible scarring around the hair follicles. Laboratory examination revealed normal thyroid test results, and normal serum testosterone and estrogen levels.
Figure 1.
Figure 1.
Figure 2.
Figure 2.
Question
Based on the patient's history and physical examination findings, which one of the following is the most likely diagnosis?
A. Alopecia totalis.
B. Alopecia universalis.
C. Androgenetic alopecia.
D. Cicatricial alopecia.
Discussion
The answer is B: alopecia universalis. The patient initially had alopecia areata of the scalp, which generally consists of patchy, discrete areas of gradual hair loss developing over several weeks.1 Approximately 10% of patients with alopecia areata progress to complete loss of scalp hair (alopecia totalis) or of scalp and body hair (alopecia universalis).2 Many patients with alopecia areata develop nail abnormalities, such as nail pitting (most common), trachyonychia (roughening of the nail plate), and onychorrhexis (longitudinal fissuring of the nail plate).3 Alopecia areata is associated with autoimmune thyroiditis.4
Androgenetic alopecia, also known as male pattern hair loss, is the progressive loss of terminal hairs on the scalp in a characteristic distribution involving the anterior, mid-, and temporal scalp, and the vertex of the scalp.5 Dihydrotestosterone is the key androgen involved in male androgenetic alopecia.6
Cicatricial alopecia is the result of secondary peribulbar inflammation that can be caused by several different conditions, including lichen planopilaris, discoid lupus erythematosus, and folliculitis decalvans. Unlike alopecia areata, cicatricial alopecia is characterized by scarring and permanent destruction of hair follicles, with loss of follicular orifices.7
Summary Table
| Condition | Characteristics |
|---|---|
Alopecia totalis and alopecia universalis | Alopecia areata (patchy, discrete areas of hair loss on the scalp) that progresses to complete loss of scalp hair (alopecia totalis) or of scalp and body hair (alopecia universalis); nail abnormalities are common |
Androgenetic alopecia | Progressive loss of terminal hairs on the scalp in a characteristic distribution involving the anterior, mid-, and temporal scalp, and the vertex of the scalp; also called male pattern hair loss |
Cicatricial alopecia | Scarring and permanent destruction of hair follicles, with loss of follicular orifices, as a result of secondary peribulbar inflammation |
Summary Table
| Condition | Characteristics |
|---|---|
Alopecia totalis and alopecia universalis | Alopecia areata (patchy, discrete areas of hair loss on the scalp) that progresses to complete loss of scalp hair (alopecia totalis) or of scalp and body hair (alopecia universalis); nail abnormalities are common |
Androgenetic alopecia | Progressive loss of terminal hairs on the scalp in a characteristic distribution involving the anterior, mid-, and temporal scalp, and the vertex of the scalp; also called male pattern hair loss |
Cicatricial alopecia | Scarring and permanent destruction of hair follicles, with loss of follicular orifices, as a result of secondary peribulbar inflammation |
The views expressed in this article are those of the authors and do not necessarily reflect the official policy or position of the Department of the Air Force, Department of the Army, Department of the Navy, Department of Defense, or the U.S. government.
REFERENCES
show all references1. Lew BL, Shin MK, Sim WY. Acute diffuse and total alopecia: a new subtype of alopecia areata with a favorable prognosis. J Am Acad Dermatol. 2009;60(1):85–93....
2. Alkhalifah A, Alsantali A, Wang E, McElwee KJ, Shapiro J. Alopecia areata update: part I. Clinical picture, histopathology, and pathogenesis. J Am Acad Dermatol. 2010;62(2):177–188.
3. Kasumagic-Halilovic E, Prohic A. Nail changes in alopecia areata: frequency and clinical presentation. J Eur Acad Dermatol Venereol. 2009;23(2):240–241.
4. Tollefson MM, Crowson CS, McEvoy MT, Maradit Kremers H. Incidence of psoriasis in children: a population-based study. J Am Acad Dermatol. 2010;62(6):979–987.
5. Price VH. Treatment of hair loss. N Engl J Med. 1999;341(13):964–973.
6. Kaufman KD. Androgens and alopecia. Mol Cell Endocrinol. 2002;198(1–2):89–95.
7. Ross EK, Tan E, Shapiro J. Update on primary cicatricial alopecias [published correction appears in J Am Acad Dermatol. 2005;53(3):496]. J Am Acad Dermatol. 2005;53(1):1–37.
This series is coordinated by John E. Delzell, Jr., MD, MSPH, Assistant Medical Editor.
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