No Added Benefit with Higher Doses of Ketorolac for Treatment of Acute Pain in the Emergency Department
Am Fam Physician. 2017 Aug 15;96(4):262.
Are lower doses of ketorolac as effective as standard doses for acute pain control in patients presenting to the emergency department?
A 10-mg dose of ketorolac is as effective as higher doses for the short-term treatment of acute pain for patients in the emergency department. (Level of Evidence = 1b)
Ketorolac is a nonsteroidal anti-inflammatory drug available in parenteral form for the treatment of acute pain. Although higher doses are often used, ketorolac may have a therapeutic ceiling of 10 mg. To investigate the effectiveness of lower doses of ketorolac, these investigators used a convenience sample of patients presenting to the emergency department on weekdays between 8:00 a.m. and 8:00 p.m. to enroll those with acute flank, abdominal, musculoskeletal, or headache pain rated at least 5 on a 10-point rating scale. The authors excluded patients with unstable vital signs, active peptic ulcer disease or gastrointestinal bleeding, or history of liver or renal disease, and those who were pregnant or breastfeeding. Using concealed allocation, investigators randomized 240 patients to receive a 10-mg, 15-mg, or 30-mg dose of ketorolac. Patients who still required pain medication 30 minutes after administration of the study drug received intravenous morphine at a dose of 0.1 mg per kg.
The three groups were similar at baseline: All groups had a mean age of 40 years, two-thirds of patients were women, and the baseline pain score was between 7 and 8. Analysis was by intention to treat. The primary outcome was a reduction of pain scores at 30 minutes after administration of the study drug. In all three groups, there was a significant decrease in pain scores from baseline to 30 minutes by at least two points. However, there were no significant differences in reduction of pain scores across the three groups at 30 minutes, or at subsequent time points of 60, 90, and 120 minutes. Further, there were no differences in the use of rescue morphine analgesia among the three groups. The most common adverse effects reported were dizziness, nausea, and headache, and they were similar in all three groups.
Study design: Randomized controlled trial (double-blinded)
Funding source: Government
Setting: Emergency department
Reference: Motov S, Yasavolian M, Likourezos A, et al. Comparison of intravenous ketorolac at three single-dose regimens for treating acute pain in the emergency department: a randomized controlled trial [published online ahead of print December 16, 2016]. Ann Emerg Med. http://www.sciencedirect.com/science/article/pii/S0196064416312446 [login required]. Accessed June 27, 2017.
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