Letters to the Editor
Lidocaine Patches Are No Better Than Placebo for Somatic Back Pain
Am Fam Physician. 2017 Nov 15;96(10):online.
Original Article: Diagnosis and Management of Vertebral Compression Fractures
Issue Date: July 1, 2016
See additional reader comments at: https://www.aafp.org/afp/2016/0701/p44.html
to the editor: I appreciated the excellent review of vertebral compression fractures (VCFs) by Drs. McCarthy and Davis. The text of the article and Table 1 stated that lidocaine patches are an option for pain relief. However, the best evidence does not show any benefit from lidocaine 5% patches compared with placebo for somatic back pain.
There are no published randomized controlled trials (RCTs) of lidocaine patches for pain from VCFs. However, two unpublished RCTs showed no significant difference between placebo patches and lidocaine 5% patches for low back pain.1,2 Another RCT showed no significant difference between placebo and lidocaine patches for chronic low back pain.3 A final RCT showed no improvement in pain control with lidocaine patches vs. placebo for traumatic rib fractures.4
At a cost of $220 per month and with an over-the-counter lidocaine 4% patch now available, the lidocaine 5% patch is an expensive placebo for our patients.
Author disclosure: No relevant financial affiliations.
REFERENCESshow all references
1. Clinical results trial summary: EN3220-011. A prospective, double-blind, randomized, placebo controlled, pilot study of the efficacy and safety of Lidoderm patch in the treatment of low back pain. http://www.endo.com/FileLibrary/ClinicalTrials/EN3220-011.pdf. Accessed August 18, 2016....
2. Clinical results trial summary: EN3261-001. A randomized double-blind study comparing the efficacy and safety of lidocaine 5% patch with placebo in patients with chronic axial low back pain. http://www.endo.com/FileLibrary/ClinicalTrials/EN3261-001.pdf. Accessed August 18, 2016.
3. Hashmi JA, Baliki MN, Huang L, et al. Lidocaine patch (5%) is no more potent than placebo in treating chronic back pain when tested in a randomised double blind placebo controlled brain imaging study. Mol Pain. 2012;8:29.
4. Ingalls NK, Horton ZA, Bettendorf M, Frye I, Rodriguez C. Randomized, double-blind, placebo-controlled trial using lidocaine patch 5% in traumatic rib fractures. J Am Coll Surg. 2010;210(2):205–209.
in reply: Thank you for the insightful commentary on our article. We agree that the evidence for lidocaine patches is not strong for somatic back pain, and we found no studies evaluating topical lidocaine for the management of VCFs. As we mentioned in our article, the American Academy of Orthopaedic Surgeons found inconclusive evidence to support specific analgesics for acute VCF pain.1 Our literature search failed to find many RCTs of medications other than calcitonin to treat pain from VCFs. Nonetheless, this pain can be substantial, and although data examining the effectiveness of analgesics are lacking, we felt it worthwhile to mention the more common medications used in practice.
Many patients with VCFs are older, and medications commonly used to treat pain from VCFs are on the Beers list of medications to avoid in older patients. In current clinical practice, there may be a role for acetaminophen or topical lidocaine, even though the effectiveness of acetaminophen has been questioned.2 Narcotics also lack sound evidence and are associated with more serious adverse effects.3 In an effort to do no harm, selecting medications such as acetaminophen and lidocaine may be warranted in older patients, even if the evidence for pain relief is less than robust. In addition to trying to recommend evidence-based treatments, we should remain cost conscious, and we appreciate the mention of the newer over-the-counter lidocaine patch as a less expensive option.
The opinions and assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the U.S. Air Force or the Department of Defense.
1. Esses SI, McGuire R, Jenkins J, et al. The treatment of symptomatic osteoporotic spinal compression fractures. J Am Acad Orthop Surg. 2011;19(3):176–182.
2. Machado GC, Maher CG, Ferreira PH, et al. Efficacy and safety of paracetamol for spinal pain and osteoarthritis: systematic review and meta-analysis of randomised placebo controlled trials. BMJ. 2015;350:h1225.
3. Abdel Shaheed C, Maher CG, Williams KA, Day R, McLachlan AJ. Efficacy, tolerability, and dose-dependent effects of opioid analgesics for low back pain: a systematic review and meta-analysis. JAMA Intern Med. 2016;176(7):958–968.
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