FPIN's Help Desk Answers

Treatment Duration for Etonogestrel Implant


Am Fam Physician. 2018 Aug 1;98(3):online.

Clinical Question

Is the etonogestrel subdermal implant (Nexplanon) effective beyond the recommended three-year treatment duration?

Evidence-Based Answer

The etonogestrel subdermal implant is approved by the U.S. Food and Drug Administration for contraception for up to three years, but it seems to be effective for up to five years. (Strength of Recommendation [SOR]: B, based on a randomized controlled trial and prospective cohort study.) When the implant is used for up to five years, failure rates are the same among women who are normal weight, overweight, or obese. (SOR: B, based on a prospective cohort study.)

Evidence Summary

A 2016 open-label, multicenter trial compared 390 patients who agreed to extend their three-year etonogestrel single-rod implant an additional two years with 522 participants who had the five-year dual-rod levonorgestrel implant (Norplant).1 Five-year pregnancy rates were similar between the groups: 0.6 per 100 woman-years (95% confidence interval [CI], 0.2 to 1.8) in the etonogestrel group vs. 0.8 per 100 woman-years (95% CI, 0.2 to 2.3) in the levonorgestrel group. No pregnancies occurred in either group during years 4 and 5. More women in the etonogestrel group reported heavy bleeding during years 4 and 5 (1.4 and 3.4 per 100 women in years 4 and 5, respectively, vs. 0.8 and 2.3 per 100 women in the levonorgestrel group; P < .05).

An ongoing prospective cohort study that started in 2009 and reported data in 2017 enrolled patients with an etonogestrel implant who were willing to continue its use for an additional two years.2 Etonogestrel levels were obtained periodically and stratified by the women's body mass index. Unintended pregnancies were calculated per 100 woman-years. Thus far, 291 women in years 4 and 5 of use have completed 444 woman-years of follow-up with no pregnancies. The failure rate has been calculated at 0 (one-sided 97.5% CI, 0 to 1.5 for four-year use and 0 to 2.7 for five-year use per 100 woman-years). Median etonogestrel levels were statistically different between groups but remained above the threshold for ovulation.

Copyright © Family Physicians Inquiries Network. Used with permission.

Address correspondence to Mollie Jacobs, MD, at mollie.jacobs@ucdenver.edu. Reprints are not available from the author.

Author disclosure: No relevant financial affiliations.


1. Ali M, Akin A, Bahamondes L, et al.; WHO study group on subdermal contraceptive implants for women. Extended use up to 5 years of the etonogestrel-releasing subdermal contraceptive implant: comparison to levonorgestrel-releasing subdermal implant. Hum Reprod. 2016;31(11):2491–2498.

2. McNicholas C, Swor E, Wan L, Peipert JF. Prolonged use of the etonogestrel implant and levonorgestrel intrauterine device: 2 years beyond the Food and Drug Administration-approved duration. Am J Obstet Gynecol. 2017;216(6):586.e1–586.e6.

Help Desk Answers provides answers to questions submitted by practicing family physicians to the Family Physicians Inquiries Network (FPIN). Members of the network select questions based on their relevance to family medicine. Answers are drawn from an approved set of evidence-based resources and undergo peer review. The strength of recommendations and the level of evidence for individual studies are rated using criteria developed by the Evidence-Based Medicine Working Group (http://www.cebm.net).

The complete database of evidence-based questions and answers is copyrighted by FPIN. If interested in submitting questions or writing answers for this series, go to http://www.fpin.org or e-mail: questions@fpin.org.

This series is coordinated by John E. Delzell Jr., MD, MSPH, Associate Medical Editor.

A collection of FPIN's Help Desk Answers published in AFP is available at https://www.aafp.org/afp/hda.



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