Photo Quiz

Urticarial, Erythematous Papules in a Pregnant Woman


Am Fam Physician. 2018 Dec 15;98(12):749-750.

A 28-year-old pregnant woman (gravida 1) presented with a severely pruritic rash at 36 weeks’ gestation. The rash began periumbilically one week prior and spread to her chest, back, arms, legs, hands, and feet.

The patient reported gaining 38 lb (17 kg) during her pregnancy. In week 26, she was diagnosed with gestational diabetes mellitus, which was adequately controlled with dietary modification.

Physical examination revealed erythematous and indurated papules on the abdomen and extremities (Figure 1 and Figure 2).

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Based on the patient’s history and physical examination findings, which one of the following is the most likely diagnosis?

A. Herpes gestationis.

B. Impetigo herpetiformis.

C. Prurigo gestationis.

D. Pruritic urticarial papules and plaques of pregnancy (PUPPP).

E. Striae gravidarum.


The answer is D: PUPPP. This is a common hive-like cutaneous complication of pregnancy. It is characterized by intensely pruritic, indurated papules and plaques that classically appear first in the abdominal striae, sparing the umbilicus, and eventually spreading to the lower extremities. PUPPP is the most common pregnancy-related dermatosis, occurring in one out of 130 to 200 pregnancies.1,2 The clinical course begins in the third trimester of pregnancy and usually resolves within one to two weeks postpartum. It is not associated with adverse pregnancy outcomes. The condition is more common in a first pregnancy for unknown reasons and in multiple gestations, most likely because of larger abdominal size.1

The etiology of PUPPP is unknown, but damage to connective tissue within the striae of the abdominal wall may have a role.3 There is an association between abdominal size and the development of PUPPP, including significantly increased maternal weight gain and newborn birth weight in women who develop the

Address correspondence to Brittany P. Smirnov, DO, at Reprints are not available from the authors.

Author disclosure: No relevant financial affiliations.


show all references

1. Tunzi M, Gray GR. Common skin conditions during pregnancy. Am Fam Physician. 2007;75(2):211–218....

2. Brzoza Z, Kasperska-Zajac A, Oleś E, Rogala B. Pruritic urticarial papules and plaques of pregnancy. J Midwifery Womens Health. 2007;52(1):44–48.

3. Matz H, Orion E, Wolf R. Pruritic urticarial papules and plaques of pregnancy: polymorphic eruption of pregnancy (PUPPP). Clin Dermatol. 2006;24(2):105–108.

4. Lawley TJ, Hertz KC, Wade TR, Ackerman AB, Katz SI. Pruritic urticarial papules and plaques of pregnancy. JAMA. 1979;241(16):1696–1699.

5. Kondo RN, Araújo FM, Pereira AM, Lopes VC, Martins LM. Pustular psoriasis of pregnancy (impetigo herpetiformis)—case report. An Bras Dermatol. 2013;88(6 suppl 1):186–189.

6. James WD, Elston DM, Berger TG, Andrews GC, eds. Andrews’ Diseases of the Skin: Clinical Dermatology. 11th ed. London, U.K.: Saunders/Elsevier; 2011:457–458.

This series is coordinated by John E. Delzell Jr., MD, MSPH, Associate Medical Editor.

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