Cochrane for Clinicians

Putting Evidence into Practice

Accuracy of Dermoscopy vs. Visual Inspection for Diagnosing Melanoma in Adults


Am Fam Physician. 2020 Feb 1;101(3):145-146.

Author disclosure: No relevant financial affiliations.

Clinical Question

Does the use of dermoscopy aid in the detection of melanoma in adults?

Evidence-Based Answer

The addition of dermoscopy to in-person visual inspection of skin lesions increases specificity and sensitivity in the detection of melanoma. In-person evaluation with dermoscopy is more accurate than image-based assessment. A published algorithm meant to assist in dermoscopic interpretation does not improve the accuracy of diagnosis, whereas dermoscopic training does increase diagnostic accuracy. There is currently insufficient evidence to assess the accuracy of dermoscopy in the primary care setting.1 (Strength of Recommendation: A, based on consistent, good-quality patient-oriented evidence.)

Practice Pointers

Dermoscopy (also known as dermatoscopy or epiluminescence microscopy) describes the use of a noninvasive handheld magnification instrument to evaluate skin lesions. Dermoscopy reveals colors and microstructures not visible to the naked eye that correspond to histologic attributes.2 Dermoscopic findings may prompt biopsy of suspicious lesions or provide reassurance for benign lesions. Images from dermoscopy can be evaluated in the presence of the patient (i.e., dermoscopic in-person evaluation) or saved and reviewed at a later time (i.e., dermoscopic image-based evaluation). The term “visual inspection” describes routine examination performed without the aid of a dermatoscope or other device. The Surveillance, Epidemiology, and End Results Program estimated 96,480 new cases of melanoma in the United States in 2019, accounting for 5.5% of all new cancer cases, making melanoma the fifth most frequent new cancer diagnosis.3

This Cochrane review included 104 studies and 42,788 total skin lesions suspected to be melanoma.1 The percentage of patients with melanoma ranged between 1% and 41% for dermoscopic in-person studies (median = 12%) and between 3% and 61% in studies using dermoscopic images (median = 24%). The diagnosis of melanoma was made by histology, and the absence of melanoma was confirmed by histology or by follow-up over time to ensure the skin lesion remained negative for melanoma. In four studies, the absence of melanoma was confirmed by expert diagnosis. Almost all of the studies were carried out in specialty offices, with only four of the studies conducted in a primary care setting.

The main results were based on 83 publications that provided 86 data sets, including accuracy data for the detection of invasive melanoma and atypical intraepidermal melanocytic variants. Twenty-six studies provided information on the accuracy of dermoscopy added to in-person visual inspection, and 60 studies provided information on dermoscopic image-based evaluation. The accuracy of diagnosis using in-person visual inspection with dermoscopy was significantly higher than evaluation of dermoscopic images, with a diagnostic odds ratio for in-person dermoscopy more than four times that of the image-based diagnosis (relative diagnostic odds ratio = 4.6; 95% CI, 2.4 to 9.0; P < .001). The review analyzed in-person and image-based studies separately because of this difference.

The reviewers also found no apparent benefit for accuracy with the use of an algorithm (e.g., “ABCD” or pattern analysis) to assist in dermoscopic interpretation for in-person or image-based evaluations. General practitioners demonstrated decreased accuracy compared with specialists in two in-person studies and three image-based studies. Regardless of the different types and length of dermoscopic training, all of the six training inte

Author disclosure: No relevant financial affiliations.

These are summaries of reviews from the Cochrane Library.


show all references

1. Dinnes J, Deeks JJ, Chuchu N, et al. Dermoscopy, with and without visual inspection, for diagnosing melanoma in adults. Cochrane Database Syst Rev. 2018;(12):CD011902....

2. Yélamos O, Braun RP, Liopyris K, et al. Usefulness of dermoscopy to improve the clinical and histopathologic diagnosis of skin cancers. J Am Acad Dermatol. 2019;80(2):365–377.

3. National Cancer Institute. Surveillance, Epidemiology, and End Results Program. Cancer stat facts: melanoma of the skin. Accessed March 25, 2019.

4. National Institute for Health and Care Excellence. Suspected cancer: recognition and referral. NICE guideline [NG12]. Updated July 2017. Accessed May 15, 2019.

This series is coordinated by Corey D. Fogleman, MD, assistant medical editor.

A collection of Cochrane for Clinicians published in AFP is available at



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