Patient-Oriented Evidence That Matters

Eating Eggs Is Not Associated with Cardiovascular Disease


Am Fam Physician. 2021 Jun 1;103(11):695.

Clinical Question

Is the consumption of eggs associated with an increased risk of cardiovascular disease?

Bottom Line

Egg consumption is not associated with the occurrence of cardiovascular events over an average of 12 years. A meta-analysis found that eating more than one egg per day, on average, was associated with a decreased likelihood of coronary artery disease (approximately 11%). This decrease may be due to a healthy user bias; that is, eating eggs may be associated with healthy habits. (Level of Evidence = 2b)


The authors searched five databases, including the Cochrane Library, and identified 23 observational studies of almost 1.4 million patients with an average follow-up of 12.3 years. One author selected the studies and two investigators independently abstracted the data. The studies' quality, evaluated by two investigators, was moderate to high for observational studies. There was no association between egg consumption and an increased risk of cardiovascular disease events, but there was a high degree of heterogeneity among the studies. Compared with eating no eggs or one egg per day on average, eating more than one egg per day on average was associated with a significantly decreased risk of coronary disease (hazard ratio = 0.89; 95% CI, 0.86 to 0.93) without evidence of heterogeneity, but there was no effect on the risk of stroke (moderate heterogeneity).

Study design: Meta-analysis (other)

Funding source: Self-funded or unfunded

Setting: Various (meta-analysis)

Reference: Krittanawong C, Narasimhan B, Wang Z, et al. Association between egg consumption and risk of cardiovascular outcomes: a systematic review and meta-analysis. Am J Med. 2021;134(1):76–83.e2.

Editor's Note: Dr. Shaughnessy is an assistant medical editor for AFP.

POEMs (patient-oriented evidence that matters) are provided by Essential Evidence Plus, a point-of-care clinical decision support system published by Wiley-Blackwell. For more information, see http://www.essentialevidenceplus.com. Copyright Wiley-Blackwell. Used with permission.

For definitions of levels of evidence used in POEMs, see http://www.essentialevidenceplus.com/product/ebm_loe.cfm?show=oxford.

To subscribe to a free podcast of these and other POEMs that appear in AFP, search in iTunes for “POEM of the Week” or go to http://goo.gl/3niWXb.

This series is coordinated by Sumi Sexton, MD, editor-in-chief.

A collection of POEMs published in AFP is available at https://www.aafp.org/afp/poems.



Want to use this article elsewhere? Get Permissions

CME Quiz

More in AFP

Editor's Collections

Related Content

More in Pubmed


May 2022

Access the latest issue of American Family Physician

Read the Issue

Email Alerts

Don't miss a single issue. Sign up for the free AFP email table of contents.

Sign Up Now

Navigate this Article