Choosing Wisely:

Don’t prescribe high-dose dexamethasone (0.5mg/kg per day) for the prevention or treatment of bronchopulmonary dysplasia in preterm infants.

Rationale and Comments: High-dose dexamethasone (0.5 mg/kg day) does not appear to confer additional therapeutic benefit over lower doses and is not recommended. High doses also have been associated with numerous short- and long-term adverse outcomes, including neurodevelopmental impairment.
Sponsoring Organizations:
  • American Academy of Pediatrics
  • Sources:
  • American Academy of Pediatrics guidelines
  • Disciplines:
  • Neonatology
  • Pulmonary medicine
  • References: • Watterberg KL; American Academy of Pediatrics Committee on Fetus and Newborn. Policy statement–postnatal corticosteroids to prevent or treat bronchopulmonary dysplasia. Pediatrics. 2010 Oct;126(4):800–8.

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