Choosing Wisely:

Don’t order a duplicate genetic test for an inherited condition unless there is uncertainty about the validity of the existing test result.

Rationale and Comments: Prior to ordering a genetic test for an inherited condition, the health care provider should ask a patient about prior genetic testing and review the medical record for previously performed genetic tests. Repeating a genetic test should be considered if the existing result is inconsistent with the individual’s clinical presentation or if the test methodology has changed and may yield a different result from the original report that could impact patient management.
Sponsoring Organizations:
  • American College of Medical Genetics and Genomics
  • Sources:
  • Expert consensus
  • Disciplines:
  • Genetic
  • References: • Miller CE, Krautscheid P, Baldwin EE, Tvrdik T, Openshaw AS, Hart K, Lagrave D. Genetic counselor review of genetic test orders in a reference laboratory reduces unnecessary testing. Am J Med Genet A. 2014 May;164A(5):1094-101.

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