Choosing Wisely:

Don’t routinely use B vitamin supplements for the treatment of polyneuropathy or neuropathic pain unless a deficiency exists.

Rationale and Comments: There is no indication for supplementing with B vitamins in patients with polyneuropathy unless a deficiency has been detected or is highly likely secondary to other medical factors (e.g., gastric bypass surgery). In addition to being an unnecessary expense, excessive vitamin B-6 can lead to toxicity and cause worsening neuropathy.
Sponsoring Organizations:
  • American Association of Neuromuscular & Electrodiagnostic Medicine
  • Sources:
  • Expert consensus
  • Disciplines:
  • Neurologic
  • References: • Bril V et al. Neurology. 2011 May 17;76(20):1758-65.
    • Kulkantrakorn K. Neurol Sci. 2014 Nov;35(11):1827-30.
    • Pluijims et al. Pain Pract. 2011 Mar-Apr;11(2):191-8.

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