Choosing Wisely:
Don’t treat uncomplicated cystitis in women with fluoroquinolones if other oral antibiotic treatment options exist.
Rationale and Comments: | Due to serious potential side effects associated with the use of fluoroquinolone antibiotics, these drugs should not be prescribed as first-line therapy for uncomplicated cystitis in women. Their use should be reserved for situations where recommended first-line antibiotic therapies, such as nitrofurantoin or sulfa-trimethoprim, are contraindicated. |
Sponsoring Organizations: |
|
Sources: |
|
Disciplines: |
|
References: | • FDA Drug Safety Communication: FDA advises restricting fluoroquinolone antibiotic use for certain uncomplicated infections; warns about disabling side effects that can occur together, July 26 2016; www.fda.gov/Drugs/DrugSafety/ucm500143.htm. • International Clinical Practice Guidelines for the Treatment of Acute Uncomplicated Cystitis and Pyelonephritis in Women: A 2010 Update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases. Clin Infect Dis (2011) 52 (5): e103-e120. DOI: doi.org/10.1093/cid/ciq257; www.idsociety.org/uploadedFiles/IDSA/Guidelines-Patient_Care/PDF_Library/Uncomp%20UTI.pdf. |
Email Alerts
Don't miss a single issue. Sign up for the free AFP email table of contents.