Choosing Wisely:

Don’t make irreversible decisions based on the results of cell-free DNA screening test.

Rationale and Comments: False-positive and false-negative results occur with cell-free DNA screening. Any positive cell-free DNA screening result should be confirmed with invasive diagnostic testing prior to a termination of pregnancy. If cell-free DNA screening is performed, adequate pretest counseling must be provided to explain the benefits and limitations.
Sponsoring Organizations:
  • Society for Maternal-Fetal Medicine
  • Sources:
  • ACOG guidelines
  • Disciplines:
  • Obstetrical
  • Genetic
  • References: • American College of Obstetricians and Gynecologists’ Committee on Practice Bulletins-Obstetrics; Committee on Genetics; Society for Maternal-Fetal Medicine. Screening for fetal chromosomal abnormalities: ACOG practice bulletin, number 226. Obstet Gynecol. 2020;136(4):e48-e69.

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