Medicine by the Numbers

From The NNT Group (, these provide short, concise, evidence-based ratings of therapies, diagnostic tests, and risk assessments commonly used in family medicine. These rating are based on patient-important benefits and harms.

Sep 01, 2021 Issue
Comparison of Treatment Regimens for Helicobacter pylori Infection
A network meta-analysis found that vonoprazan-based triple therapy and reverse hybrid therapy demonstrated the highest overall cure rates and SUCRA values; however, among Western countries, levofloxacin-based triple therapy had the highest cure rate and SUCRA value. Standard triple therapy was the least effective regimen overall.

Aug 01, 2021 Issue
Accuracy of Ultrasonography for the Diagnosis of Small Bowel Obstruction
According to a meta-analysis including prospective observational studies evaluating the accuracy of ultrasonography for the diagnosis of small bowel obstruction, ultrasonography appears to be highly sensitive and specific for this use.

Jul 01, 2021 Issue
Levonorgestrel-Releasing Intrauterine System for Regression of Endometrial Hyperplasia
A Cochrane review compared the levonorgestrel-releasing intrauterine system with progesterone for the treatment of endometrial hyperplasia.

Jun 1, 2021 Issue
Oxytocin as First-line Uterotonic Therapy for Postpartum Hemorrhage
Oxytocin decreases the chances of a blood transfusion and has fewer adverse effects compared with misoprostol.

May 1, 2021 Issue
Ibuprofen vs. Acetaminophen for Fever or Pain in Children Younger Than Two Years
A meta-analysis found that ibuprofen is more effective than acetaminophen in reducing fever and pain in children younger than two years, although further study is needed to evaluate combination therapy, dosing, and use in children younger than six months.

Apr 1, 2021 Issue
Treatment of Distal DVT
A Cochrane review demonstrated that anticoagulation was effective and superior to observation for deep venous thrombosis; however, given the quality of the evidence, the benefits are unclear.

Mar 1, 2021 Issue
Antiplatelet Agents for Preventing Early Recurrence of Ischemic Stroke or TIA
After atherothrombotic ischemic stroke or transient ischemic attack, adding clopidogrel to aspirin reduced recurrent strokes but increased major hemorrhages.

Feb 15, 2021 Issue
Intravenous Magnesium Sulfate for Acute Asthma Exacerbation in Children and Adults
Patients who received intravenous magnesium sulfate for acute asthma exacerbation in the emergency department had decreased hospital admissions and no serious adverse effects.

Jan 1, 2021 Issue
Effectiveness of Alarm Therapy in the Treatment of Nocturnal Enuresis in Children
This review concluded that alarm therapy appears to be effective for treating nocturnal enuresis in children, but it is uncertain if it is more effective than other interventions.

Dec 1, 2020 Issue
Antibiotics for Uncomplicated Diverticulitis
Learn more about the benefits and harms of antibiotics for uncomplicated diverticulitis.

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