AFP DEPARTMENT COLLECTION

FPIN's Clinical Inquiries

Clinical Inquiries from the Family Physicians Inquiries Network (FPIN) provide short, concise, evidence-based answers to clinical questions common in family medicine. The answers include a summary of the evidence and commentary that puts the answers into perspective.

Nov 1, 2020 Issue
Rebound Bilirubin Levels after Phototherapy in Neonates with Hyperbilirubinemia
Rebound elevation of bilirubin levels after phototherapy discontinuation in healthy term neonates is infrequent (fewer than 2% of infants with levels less than 14 mg per dL [239 mmol per L] at initial discontinuation). Obtaining a repeat bilirubin level four to six hours after phototherapy discontinuation is not recommended.


Oct 1, 2020 Issue
Alcohol Use Disorder: Pharmacologic Treatment Options
Acamprosate and naltrexone should be used as first-line agents for treatment of alcohol use disorder and are effective for reducing relapse rates. Agent selection should be based on comorbid conditions and adherence to the dosing regimen.


Sep 1, 2020 Issue
Misoprostol Dosing for First-Trimester Abortion
Vaginal, oral, and sublingual misoprostol in single doses of 600 to 800 mcg are equally effective for promoting completed abortion in patients with an incomplete first-trimester spontaneous abortion.


Aug 1, 2020 Issue
Acupuncture for Knee Osteoarthritis
Electroacupuncture can be used to improve pain and physical function in adults with knee osteoarthritis.


Jul 1, 2020 Issue
Antiemetics for Acute Gastroenteritis in Children
Oral ondansetron (Zofran) may be given to children presenting to the emergency department with vomiting and mild to moderate dehydration from acute gastroenteritis. It reduces hospital admissions and the need for intravenous hydration.


Jun 1, 2020 Issue
Supplemental Oxygen Therapy for Nonhypoxemic Patients with Acute Coronary Syndrome
No conclusive evidence demonstrates that routine use of supplemental oxygen therapy is associated with clinical benefit or harm in nonhypoxemic patients with acute myocardial infarction (MI).


May 1, 2020 Issue
Megestrol for Palliative Care in Patients with Cancer
Megestrol may be considered as a component of palliative care nutritional support in patients with cancer.


Apr 1, 2020 Issue
Probiotics to Augment Antifungal Treatment of Vulvovaginal Candidiasis
Adding probiotics (typically Lactobacillus species) to antifungal therapy for vulvovaginal candidiasis improves short-term cure rates by 14% and reduces one-month relapse rates by 66%.


Mar 1, 2020 Issue
Tai Chi for Fibromyalgia
The practice of Yang-style tai chi for one hour twice weekly for 12 to 24 weeks is moderately effective in improving quality of life in patients with fibromyalgia.


Feb 1, 2020 Issue
Treatments for Postmenopausal Hypoactive Sexual Desire Disorder
Transdermal testosterone for the treatment of hypoactive sexual desire disorder in postmenopausal women results in an additional 0.92 sexually satisfying events per month, acne, and increased androgenic effects without major complications


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