Cochrane for Clinicians

These are summaries of reviews from the Cochrane Library.

Apr 1, 2021 Issue
Epidural Corticosteroid Injections for Lumbosacral Radicular Pain
Epidural corticosteroid injections for the treatment of lumbosacral radicular pain may offer modest short-term (two weeks to three months) benefit compared with placebo injection for radicular leg pain.

Apr 1, 2021 Issue
Active vs. Expectant Management in the Third Stage of Labor
Very low-quality evidence suggests that active management of the third stage of labor reduces the risk of severe primary postpartum hemorrhage greater than 1,000 mL.

Mar 1, 2021 Issue
Structural MRI for the Early Diagnosis of Alzheimer Disease in Patients with MCI
There is insufficient evidence to recommend structural brain magnetic resonance imaging to diagnose Alzheimer disease in patients with mild cognitive impairment.

Mar 1, 2021 Issue
Alcoholics Anonymous and Other 12-Step Facilitation Programs for Alcohol Use Disorder
Manualized (standardized and replicable) Alcoholics Anonymous and similar 12-step facilitation programs produce higher rates of continuous abstinence than other established treatments.

Feb 1, 2021 Issue
Exercise vs. No Exercise for the Occurrence, Severity, and Duration of Acute Respiratory Tract Infections
For adults, regular exercise may reduce the overall severity of acute respiratory tract infections and the number of days with symptoms, but there is no evidence that exercise reduces the overall occurrence or duration of these infections.

Feb 1, 2021 Issue
Topical and Device-Based Treatment of Toenail Onychomycosis
Topical antifungal drugs, including efinaconazole 10% solution (Jublia), tavaborole 5% solution (Kerydin), and ciclopirox 8% lacquer and hydrolacquer, are beneficial in treating mild to moderate toenail onychomycosis. Potential adverse effects are mild and include dermatitis and vesicles.

Jan 1, 2021 Issue
Treatment of Distal DVT
Vitamin K antagonists reduce the recurrence of DVT and VTE (number needed to treat [NNT] = 17; 95% CI, 13 to 48) but not pulmonary embolism (PE) compared with no anticoagulation or placebo.

Jan 1, 2021 Issue
Medications for Treatment-Resistant Depression in Adults
In patients with treatment-resistant depression, augmenting therapy with atypical antipsychotics can be effective.

Dec 1, 2020 Issue
Low-Protein Diets for Adults Without Diabetes Mellitus Who Have CKD
In patients without diabetes mellitus who have chronic kidney disease, is a low-protein diet effective at preventing progression to end-stage renal disease or the need for dialysis?

Dec 1, 2020 Issue
Beta Blockers for Suspected or Diagnosed Acute Myocardial Infarction
Compared with placebo, beta-blocker use in patients with acute MI reduces short-term (less than three months) risk of MI and long-term (more than three months) risk of cardiovascular mortality and all-cause mortality.

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