Cochrane for Clinicians

These are summaries of reviews from the Cochrane Library.

Jan 01, 2022 Issue
Compression Stockings for Preventing Deep Venous Thrombosis in Airline Passengers
Compression stockings are effective at reducing asymptomatic deep venous thrombosis in airline passengers taking flights longer than five hours in both high-risk and low-risk populations.

Jan 01, 2022 Issue
Can Walking Lower Blood Pressure in Patients With Hypertension?
Walking lowers systolic blood pressure by 4.11 mm Hg. It lowers diastolic blood pressure by 1.79 mm Hg and resting heart rate by 2.76 beats per minute.

Dec 01, 2021 Issue
Single-Dose Oral NSAIDs and Acetaminophen for Perineal Pain in the Early Postpartum Period
In patients with acute perineal pain at four hours' postpartum, a single dose of an oral NSAID and a single dose of oral acetaminophen are each effective at achieving adequate pain relief. Both NSAIDs and acetaminophen are effective at reducing the need for further analgesia. It is unclear whether an NSAID or acetaminophen is superior. It should be noted that these data are based on studies in which a majority of patients underwent episiotomy.

Dec 01, 2021 Issue
Trigger Finger: Safety and Effectiveness of NSAID vs. Steroid Injection Therapy
In patients with trigger finger, there is no significant difference in outcomes at 12 to 24 weeks— including resolution of symptoms, recurrence, total active motion, residual pain, patient satisfaction, or adverse events—when comparing treatment with NSAID injections vs. corticosteroid injections.

Nov 01, 2021 Issue
Coenzyme Q10 for Heart Failure
In patients with chronic heart failure, supplementation with coenzyme Q10 may reduce all-cause mortality. Adverse effects are generally mild and may be only slightly increased with coenzyme Q10 supplementation.

Nov 01, 2021 Issue
Basal Cell Carcinoma: Comparison of Surgical and Nonsurgical Interventions
The recurrence rate after surgical management of BCC by standard surgical excision or Mohs micrographic surgery is very low. Recurrence after management with imiquimod (Aldara) is also low and may result in more favorable cosmetic outcomes. Other nonsurgical options may have acceptably low rates of recurrence but also have low certainty of evidence.

Oct 01, 2021 Issue
Schizophrenia: Use of Antipsychotic Drugs for Maintenance Therapy
Compared with placebo, using antipsychotic drugs for maintenance therapy in patients with schizophrenia is associated with relapse prevention at seven to 12 months.

Oct 01, 2021 Issue
Interventions to Improve Use of CPAP Machines in Adults with Obstructive Sleep Apnea
Behavioral interventions increase CPAP use compared with usual care. These interventions also increase CPAP adherence, measured by participants using their machine four or more hours per night, from 371 to 501 per 1,000 patients.

Sep 01, 2021 Issue
Reducing Saturated Fat Intake to Decrease the Risk of Cardiovascular Disease
Reducing saturated fat in the diet for at least two years decreases the risk of combined cardiovascular events. However, there is little to no effect on cardiovascular mortality, all-cause mortality, or individual cardiovascular events.

Sep 01, 2021 Issue
Pelvic Floor Muscle Training to Prevent and Treat Urinary and Fecal Incontinence in Antenatal and Postnatal Patients
Structured PFMT beginning early in pregnancy prevents the onset of urge incontinence later in pregnancy and in the postpartum period compared with no intervention. There is no evidence that PFMT improves urinary incontinence later in pregnancy or in the postpartum period in pregnant patients who already have urinary incontinence. There is no clear evidence that PFMT effectively prevents or treats fecal incontinence later in pregnancy or after delivery.

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