Cochrane for Clinicians

These are summaries of reviews from the Cochrane Library.

Oct 1, 2020 Issue
Effects of Inhaled Corticosteroids on Growth in Children with Persistent Asthma
Inhaled fluticasone (Flovent; 200 mcg per day) is associated with a greater linear growth velocity when compared with beclomethasone (400 mcg per day; an equivalent dose).

Oct 1, 2020 Issue
Acute Appendicitis: Computed Tomography for Diagnosis in Adults
In a nonpregnant adult with clinical signs and symptoms of appendicitis, computed tomography has a sensitivity of 95% and specificity of 94%.

Sep 1, 2020 Issue
Effectiveness of PPAR Gamma Agonists in Preventing Recurrent Stroke and Other Vascular Events
PPAR gamma agonists are probably effective in preventing recurrent stroke in people with previous stroke or TIA.

Sep 1, 2020 Issue
Corticosteroids for Hospitalized Patients with Community-Acquired Pneumonia
For adults hospitalized with severe CAP, the use of corticosteroids may reduce the likelihood of mortality.

Aug 1, 2020 Issue
Smoking Cessation with Text Messaging and App-Based Interventions
Automated text messaging interventions are more effective than minimal smoking cessation support (absolute risk reduction [ARR] = 3%; 95% CI, 1% to 5%).

Aug 1, 2020 Issue
Heavy Menstrual Bleeding in Premenopausal Patients and the Role of NSAIDs
NSAIDs are effective for reducing heavy menstrual bleeding in premenopausal patients with menorrhagia when compared with placebo.

Jul 1, 2020 Issue
Nicotine Replacement Therapy for Smoking Cessation
Patients using a combination of nicotine patch and fast-acting NRT are more likely to quit smoking than those on any single therapy alone (number needed to treat [NNT] = 29; 95% CI, 20 to 47).

Jul 1, 2020 Issue
Role of Mucolytics in the Treatment of Chronic Bronchitis or COPD
Oral mucolytic agents may reduce the number of acute exacerbations in patients with chronic bronchitis or COPD (number needed to treat [NNT] = 8 over an average of nine months; 95% CI, 7 to 10).

Jun 1, 2020 Issue
Potential of Fetal Fibronectin Testing to Prevent Preterm Birth
Fetal fibronectin testing may reduce preterm birth, although the evidence is not strong enough to recommend regular testing.

Jun 1, 2020 Issue
Emergency Contraception: Safety and Effectiveness
Oral mifepristone (Mifeprex), ulipristal (Ella), levonorgestrel-releasing emergency contraception (Plan B One-Step), ethinyl estradiol/levonorgestrel, and the copper intrauterine device (IUD; Paragard) are safe and effective for emergency contraception.

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