Cochrane for Clinicians

These are summaries of reviews from the Cochrane Library.

Jan 1, 2021 Issue
Medications for Treatment-Resistant Depression in Adults
In patients with treatment-resistant depression, augmenting therapy with atypical antipsychotics can be effective.

Jan 1, 2021 Issue
Treatment of Distal DVT
Vitamin K antagonists reduce the recurrence of DVT and VTE (number needed to treat [NNT] = 17; 95% CI, 13 to 48) but not pulmonary embolism (PE) compared with no anticoagulation or placebo.

Dec 1, 2020 Issue
Low-Protein Diets for Adults Without Diabetes Mellitus Who Have CKD
In patients without diabetes mellitus who have chronic kidney disease, is a low-protein diet effective at preventing progression to end-stage renal disease or the need for dialysis?

Dec 1, 2020 Issue
Beta Blockers for Suspected or Diagnosed Acute Myocardial Infarction
Compared with placebo, beta-blocker use in patients with acute MI reduces short-term (less than three months) risk of MI and long-term (more than three months) risk of cardiovascular mortality and all-cause mortality.

Nov 1, 2020 Issue
Mechanical Methods of Induction of Labor
Mechanical induction of labor with single or double balloon catheters is similar to induction with vaginal prostaglandin E2 in rates of vaginal delivery achieved within 24 hours, and it has a more favorable safety profile.

Nov 1, 2020 Issue
Metformin to Prevent Diabetes in Patients at Increased Risk
In patients at increased risk of developing type 2 diabetes, metformin reduces the risk (number needed to treat [NNT] = 7; 95% CI, 6 to 10) compared with counseling on standard diet and exercise.

Oct 1, 2020 Issue
Acute Appendicitis: Computed Tomography for Diagnosis in Adults
In a nonpregnant adult with clinical signs and symptoms of appendicitis, computed tomography has a sensitivity of 95% and specificity of 94%.

Oct 1, 2020 Issue
Effects of Inhaled Corticosteroids on Growth in Children with Persistent Asthma
Inhaled fluticasone (Flovent; 200 mcg per day) is associated with a greater linear growth velocity when compared with beclomethasone (400 mcg per day; an equivalent dose).

Sep 1, 2020 Issue
Effectiveness of PPAR Gamma Agonists in Preventing Recurrent Stroke and Other Vascular Events
PPAR gamma agonists are probably effective in preventing recurrent stroke in people with previous stroke or TIA.

Sep 1, 2020 Issue
Corticosteroids for Hospitalized Patients with Community-Acquired Pneumonia
For adults hospitalized with severe CAP, the use of corticosteroids may reduce the likelihood of mortality.

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