Cochrane for Clinicians

These are summaries of reviews from the Cochrane Library.

May 1, 2019 Issue
Aromatase Inhibitors Such as Letrozole (Femara) vs. Clomiphene (Clomid) for Subfertile Women with PCOS
When treated with letrozole, subfertile women with PCOS who are trying to conceive have increased chances of pregnancy (number needed to treat [NNT] = 11) and live birth (NNT = 10) compared with those treated with clomiphene.

May 1, 2019 Issue
Saline Irrigation for Allergic Rhinitis
asal saline irrigation reduces the severity of allergy symptoms for up to eight weeks vs. no treatment. It is uncertain if adding nasal saline to pharmacologic treatment further improves symptoms over pharmacologic treatment alone.

Apr 1, 2019 Issue
Direct Oral Anticoagulants vs. Warfarin to Prevent Stroke and Embolic Events in Patients with Atrial Fibrillation and CKD
Direct oral anticoagulants are as likely as warfarin to prevent all strokes and systemic embolic events in patients with atrial fibrillation and CKD stage 3. They do not increase the risk of major bleeding events. The evidence remains insufficient to make recommendations for the use of direct oral anticoagulants in the management of patients with atrial fibrillation and CKD stage 4 or 5.

Apr 1, 2019 Issue
Pulse Oximetry Screening for Critical Congenital Heart Defects in Newborns
Pulse oximetry is an accurate screening test for critical congenital heart defects in newborns. Pulse oximetry is simple to use, widely available, and has moderate sensitivity (76.3%) and good specificity (99.9%). However, the prevalence of critical congenital heart defects is low, and most newborns who screen positive do not have a critical congenital heart defect.

Mar 1, 2019 Issue
Different Durations of Corticosteroid Therapy for COPD Exacerbations
Treatment of acute exacerbations of COPD with a shorter course of systemic corticosteroids (seven or fewer days) is likely to be as effective and safe as treating with longer courses (more than seven days).

Mar 1, 2019 Issue
Smectite for Acute Infectious Diarrhea in Children
When compared with placebo, smectite decreases the duration of diarrhea by about a day, with a mean difference of 24.4 fewer hours of diarrhea (95% confidence interval [CI], 17.9 to 30.9 hours). Smectite also decreases stool output by 11.4 g per kg (95% CI, 0.8 to 22 g per kg).

Feb 1, 2019 Issue
Oral Immunotherapy for Egg Allergy
Providing daily, steadily increasing doses of egg protein over an extended period of time effectively diminishes the immunoglobulin E (IgE)-mediated allergic response among children with egg allergy.

Feb 1, 2019 Issue
Complementary and Integrative Treatments for Pain Management in Labor
There is evidence that all of the studied interventions have some benefit in labor, but the evidence is of low to very low quality. Massage, thermal interventions (warm and cold packs), relaxation techniques, yoga, and music reduce pain during latent labor, but not during active labor.

Jan 1, 2019 Issue
Prophylactic Vaccination Against Human Papillomavirus to Prevent Cervical Cancer and Its Precursors
HPV vaccination in women 15 to 26 years of age prevents the development of cervical intraepithelial neoplasia (CIN) 2 and CIN 3 in women regardless of previous HPV exposure (number needed to treat [NNT] = 39). No serious adverse effects are associated with administration of the HPV vaccine.

Jan 1, 2019 Issue
Pharmacologic Interventions for Apathy in Patients with Alzheimer Disease
Methylphenidate may improve apathy in select patients with AD (mean difference [MD] = –4.99 on the apathy evaluation scale; 95% confidence interval [CI], –9.55 to –0.43), although the clinical significance associated with these findings remains unclear and the evidence is considered low quality.

Pages: 1 2 3 4 5 6 7 8 9 10 ... 39 Next

Email Alerts

Don't miss a single issue. Sign up for the free AFP email table of contents.

Sign Up Now