ITEMS IN AFP WITH KEYWORD:

Anticoagulation

Sep 15, 2015 Issue
Real-World Study Finds Lower Mortality and Stroke Risk with Dabigatran, but More GI Bleeds [POEMs]

In this well-designed observational study, older patients given an initial prescription of dabigatran had lower all-cause mortality and fewer ischemic and hemorrhagic strokes, but a higher risk of gastrointestinal (GI) bleeding, than a matched group of patients given warfarin.


Sep 1, 2015 Issue
Bridging Anticoagulation in Patients with Atrial Fibrillation Associated with More Cardiovascular Events and Bleeding [POEMs]

This study provides more evidence that bridging in patients with nonvalvular atrial fibrillation does not improve outcomes, and is actually associated with a higher risk of bleeding complications and cardiovascular events.


Jul 1, 2015 Issue
NSAID Use Associated with Increased Risk of Serious Bleeding and CV Events After MI [POEMs]

The use of concomitant NSAIDs in adults who receive antithrombotic therapy after MI increases the risk of serious bleeding complications and recurrent adverse CV events. This study found the highest risk among users of celecoxib (Celebrex) and diclofenac, and the lowest risk among users of ibuprofen...


Jun 15, 2015 Issue
Patients with Initial Unprovoked DVT or PE Benefit from Long-Term Low-Dose Aspirin [POEMs]

Aspirin improves long-term cardiovascular and thrombotic outcomes in patients who have had an initial unprovoked episode of VTE. The risk of bleeding was no higher in the aspirin group, perhaps because those at risk of bleeding were “uncovered” during the initial period of anticoagulation.


May 1, 2015 Issue
Increased GI Bleeding After Switch from Warfarin to Dabigatran [POEMs]

The risk of bleeding increases (though remains small) when patients with atrial fibrillation are switched from warfarin to dabigatran to prevent stroke or transient ischemic attack. This study, conducted almost exclusively in male veterans, found an increase in gastrointestinal (GI) bleeding, but not in intracranial bleeds.


Jul 15, 2014 Issue
New Anticoagulants vs. Warfarin in Atrial Fibrillation: No Clear Winner [POEMs]

In this meta-analysis, newer anticoagulants appear to be slightly more effective than warfarin in the short term (two years) in preventing strokes of all kinds in patients with atrial fibrillation. However, they are no more effective than warfarin in preventing ischemic strokes, and they cause more ...


May 15, 2014 Issue
Fewer Major Bleeds with Edoxaban Than with Warfarin, but Treatment Benefit Unclear [POEMs]

Edoxaban provides similar effectiveness and a somewhat lower rate of major gastrointestinal and intracranial bleeding than warfarin. It is worth reading the supplemental appendices to this report for a look at the subgroups. For almost all subgroups, low-dose edoxaban caused less major bleeding than...


Sep 15, 2013 Issue
Continued Warfarin Better Than Bridging Therapy for Pacemaker or Defibrillator Surgery [POEMs]

This is the best and largest single trial comparing continued warfarin with a bridging strategy. Patients with an annual risk of thromboembolic events of 5% or more undergoing pacemaker or defibrillator surgery who continued to use warfarin had fewer device-pocket hematomas than patients who received bridging therapy with heparin.


Jun 15, 2013 Issue
Is Rivaroxaban Noninferior to Standard Warfarin Therapy in Preventing Recurrent PE and DVT? [AFP Journal Club]

A trial showing that one drug is noninferior to another does not mean that these drugs are equivalent. The noninferiority margin allows researchers to choose their own benchmark for what is considered a clinically significant difference between two drugs.


Jun 1, 2013 Issue
Aspirin Following Anticoagulation Therapy Prevents Recurrent VTE [POEMs]

Although this ASPIRE study was underpowered to detect a difference in the primary outcome, when the results were combined with those of the WARFASA trial, the data show that daily low-dose aspirin prevents recurrent VTE as well as major vascular events without increasing bleeding in patients who hav...


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