ITEMS IN AFP WITH KEYWORD:

Anticoagulation

Apr 1, 2009 Issue
Heparins for Unstable Angina and Non-ST-Segment Elevation Myocardial Infarction [Cochrane for Clinicians]

Compared with standard therapy with aspirin, the use of heparin does not reduce mortality, the need for revascularization, and recurrent angina. Heparin does reduce the occurrence of myocardial infarction (MI; number needed to treat [NNT] = 33), defined as “typical chest pain associated with the app...


Jun 1, 2008 Issue
Is Unfractionated Heparin Equivalent to Low-Molecular-Weight Heparin for Venous Thromboembolism? [AFP Journal Club]

Is weight-based unfractionated heparin as good as weight-based low-molecular-weight heparin for outpatient treatment of venous thromboembolism? Even though this study was underpowered to prove equivalence, treatment with subcutaneous unfractionated heparin is a viable option.


May 1, 2008 Issue
Oral Anticoagulants vs. Antiplatelet Therapy [Cochrane for Clinicians]

Compared with antiplatelet therapy, oral anticoagulation significantly reduces stroke at an average follow-up of one to three years, but does not reduce mortality. Intracranial or extracranial hemorrhage is more common with anticoagulation and must be weighed against its therapeutic benefit.


Apr 1, 2007 Issue
Outpatient Management of Anticoagulation Therapy [Article]

The Seventh American College of Chest Physicians (ACCP) Conference on Antithrombotic and Thrombolytic Therapy provides guidelines for outpatient management of anticoagulation therapy. The ACCP guidelines recommend short-term warfarin therapy, with the goal of maintaining an International Normalized ...


May 15, 2005 Issue
Evidence-Based Adjustment of Warfarin (Coumadin) Doses [Point-of-Care Guides]

A previous Point-of-Care Guides article,1 presented several validated approaches to the initiation of anticoagulation therapy with warfarin. Once a patient is receiving warfarin, it is important to have a systematic approach to the management of anticoagulation and adjustment of warfarin doses.


Feb 15, 2005 Issue
Evidence-Based Initiation of Warfarin (Coumadin) [Point-of-Care Guides]

Many physicians continue to use clinical judgment alone as the basis for initiating and adjusting warfarin dosages in patients who require oral anticoagulation. A number of studies have validated approaches to initiation of anticoagulation that provide more rapid anticoagulation with less chance of complications.


Jun 15, 2004 Issue
DVT and Pulmonary Embolism: Part II. Treatment and Prevention [Article]

Treatment goals for deep venous thrombosis include stopping clot propagation and preventing the recurrence of thrombus, the occurrence of pulmonary embolism, and the development of pulmonary hypertension, which can be a complication of multiple recurrent pulmonary emboli. About 30 percent of patient...


Mar 15, 2002 Issue
Is Thrombolytic Therapy Effective For Pulmonary Embolism? [Article]

Pulmonary embolism is a disorder that is associated with significant morbidity and mortality. Right-sided heart failure and recurrent pulmonary embolism are the main causes of death associated with pulmonary embolism in the first two weeks after the embolic event. Thrombolysis is a potentially lifes...


Feb 15, 1999 Issue
Low-Molecular-Weight Heparin in Treatment of DVT [Article]

Patients with a diagnosis of acute deep venous thrombosis have traditionally been hospitalized and treated with unfractionated heparin followed by oral anticoagulation therapy. Several clinical trials have shown that low-molecular-weight heparin is at least as safe and effective as unfractionated he...


Feb 1, 1999 Issue
Warfarin Therapy: Evolving Strategies in Anticoagulation [Article]

Warfarin is the oral anticoagulant most frequently used to control and prevent thromboembolic disorders. Prescribing the dose that both avoids hemorrhagic complications and achieves sufficient suppression of thrombosis requires a thorough understanding of the drug's unique pharmacology. Warfarin has...


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