Sep 1, 2013 Issue
Vitamin D Does Not Reduce Knee Pain from Osteoarthritis [POEMs]

Vitamin D supplementation at a dose targeted to reach a 25-hydroxyvitamin D plasma level greater than 36 ng per mL for two years did not reduce symptomatic knee pain in adults with osteoarthritis.

Feb 1, 2013 Issue
Hyaluronic Acid Ineffective for Knee Osteoarthritis [POEMs]

Hyaluronic acid injection does not improve pain in patients with knee osteoarthritis but may result in serious adverse effects.

Jan 1, 2012 Issue
Osteoarthritis: Diagnosis and Treatment [Article]

Osteoarthritis is a common degenerative disorder of the articular cartilage associated with hypertrophic bone changes. Risk factors include genetics, female sex, past trauma, advancing age, and obesity. The diagnosis is based on a history of joint pain worsened by movement, which can lead to disabil...

Dec 1, 2011 Issue
Diagnosis and Management of Rheumatoid Arthritis [Article]

Rheumatoid arthritis is the most commonly diagnosed systemic inflammatory arthritis. Women, smokers, and those with a family history of the disease are most often affected. Criteria for diagnosis include having at least one joint with definite swelling that is not explained by another disease. The l...

Sep 15, 2011 Issue
Approach to Septic Arthritis [Article]

Prompt diagnosis and treatment of infectious arthritis can help prevent significant morbidity and mortality. The acute onset of monoarticular joint pain, erythema, heat, and immobility should raise suspicion of sepsis. Constitutional symptoms such as fever, chills, and rigors are poorly sensitive fo...

Sep 1, 2011 Issue
Exercise for the Treatment of Knee Osteoarthritis [FPIN's Clinical Inquiries]

Regular exercise reduces osteoarthritic knee pain and improves functioning.

Jun 1, 2011 Issue
Treatment of Knee Osteoarthritis [Article]

Knee osteoarthritis is a common disabling condition that affects more than one-third of persons older than 65 years. Exercise, weight loss, physical therapy, intra-articular corticosteroid injections, and the use of nonsteroidal anti-inflammatory drugs and braces or heel wedges decrease pain and imp...

Dec 15, 2008 Issue
Adalimumab (Humira) for the Treatment of Rheumatoid Arthritis [STEPS]

Adalimumab used alone offers little benefit over the traditional first-line agent, methotrexate. However, it increases remission rates when combined with methotrexate in early aggressive rheumatoid arthritis and when combined with traditional DMARDs in those who have not derived benefit from existin...

Sep 1, 2008 Issue
Shoulder Osteoarthritis: Diagnosis and Management [Article]

Osteoarthritis of the shoulder is a gradual wearing of the articular cartilage that leads to pain and stiffness. As the joint surface degenerates, the subchondral bone remodels, losing its sphericity and congruity. The joint capsule also becomes thickened, leading to further loss of shoulder rotatio...

May 15, 2008 Issue
Predicting Rheumatoid Arthritis Risk in Adults with Undifferentiated Arthritis [Point-of-Care Guides]

Early use of disease-modifying antirheumatic drugs (DMARDs) markedly reduces inflammation and joint destruction associated with RA.1,2 Therefore, with early diagnosis of RA and appropriate use of DMARDs, there is a window of opportunity to change the clinical course of this disabling disease.

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