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Arthritis and Joint Pain

Sep 1, 2008 Issue
Shoulder Osteoarthritis: Diagnosis and Management [Article]

Osteoarthritis of the shoulder is a gradual wearing of the articular cartilage that leads to pain and stiffness. As the joint surface degenerates, the subchondral bone remodels, losing its sphericity and congruity. The joint capsule also becomes thickened, leading to further loss of shoulder rotatio...


May 15, 2008 Issue
Predicting Rheumatoid Arthritis Risk in Adults with Undifferentiated Arthritis [Point-of-Care Guides]

Early use of disease-modifying antirheumatic drugs (DMARDs) markedly reduces inflammation and joint destruction associated with RA.1,2 Therefore, with early diagnosis of RA and appropriate use of DMARDs, there is a window of opportunity to change the clinical course of this disabling disease.


Jan 15, 2008 Issue
Dietary Supplements for Osteoarthritis [Article]

A large number of dietary supplements are promoted to patients with osteoarthritis and as many as one third of those patients have used a supplement to treat their condition. Glucosamine-containing supplements are among the most commonly used products for osteoarthritis. Although the evidence is not...


Sep 15, 2007 Issue
Gout: An Update [Article]

Arthritis caused by gout (i.e., gouty arthritis) accounts for millions of outpatient visits annually, and the prevalence is increasing. Gout is caused by monosodium urate crystal deposition in tissues leading to arthritis, soft tissue masses (i.e., tophi), nephrolithiasis, and urate nephropathy. The...


Sep 1, 2007 Issue
The Role of Allergens in Asthma [Article]

The National Asthma Education and Prevention Program Expert Panel guidelines for the management of asthma recommend that patients who require daily asthma medications have allergy testing for perennial indoor allergens and that, when triggers are found, exposure to allergens and pollutants be contro...


Feb 1, 2006 Issue
Adalimumab for Rheumatoid Arthritis? [Cochrane for Clinicians]

Combined with methotrexate, subcutaneous adalimumab at a dosage of 40 mg every two weeks slows the progression of rheumatoid arthritis at one year. The combination is more effective than adalimumab monotherapy. Limited evidence suggests that adalimumab is also safe and effective when combined with o...


Sep 15, 2005 Issue
Diagnosis and Management of Rheumatoid Arthritis [Article]

Rheumatoid arthritis is a chronic inflammatory disease characterized by uncontrolled proliferation of synovial tissue and a wide array of multisystem comorbidities. Prevalence is estimated to be 0.8 percent worldwide, with women twice as likely to develop the disease as men. Untreated, 20 to 30 perc...


Nov 1, 2003 Issue
Rheumatoid Arthritis [Clinical Evidence Handbook]

What are the effects of treatments?


Sep 15, 2003 Issue
Diagnostic Approach to Polyarticular Joint Pain [Article]

Identifying the cause of polyarticular joint pain can be difficult because of the extensive differential diagnosis. A thorough history and a complete physical examination are essential. Six clinical factors are helpful in narrowing the possible causes: disease chronology, inflammation, distribution,...


Sep 1, 2003 Issue
Is Leflunomide as Safe and Effective in the Treatment of Rheumatoid Arthritis as Other DMARDs? [Cochrane for Clinicians]

Compared with placebo, leflunomide improves clinical outcomes and delays radiologic progression of rheumatoid arthritis. After two years of treatment, leflunomide is as safe as sulfasalazine and more effective. Leflunomide's efficacy and adverse events are similar to those of methotrexate. Leflunomi...


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